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Expression of Reversion-inducing Cysteine-rich Protein with Kazal Motifs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus: Links to Disease Activity, Damage Accrual and Matrix Metalloproteinase 9 Secretion
- Source :
- Journal of International Medical Research. 36:704-713
- Publication Year :
- 2008
- Publisher :
- SAGE Publications, 2008.
-
Abstract
- We studied the expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) on peripheral blood mononuclear cells (PBMCs), the serum concentration of matrix metalloproteinase 9 (MMP-9) and the MMP-9 secretion ability of PBMCs in patients with systemic lupus erythematosus (SLE), and clinical features were assessed. Compared with PBMCs from healthy donors, PBMCs from SLE patients expressed less RECK protein and mRNA but secreted more MMP-9. The serum concentration of MMP-9 was, however, lower in SLE patients than in healthy donors. The level of RECK protein was inversely associated with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI) and MMP-9 secretion in SLE, but no relationship was found between serum MMP-9 concentration and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). In conclusion, the level of RECK protein expressed in PBMCs could be used to predict organ or system damage in SLE and this might help in developing new therapies for SLE targeted at MMP-9.
- Subjects :
- Adult
Male
Reversion
Matrix metalloproteinase
GPI-Linked Proteins
Severity of Illness Index
Biochemistry
Peripheral blood mononuclear cell
Kazal Motifs
immune system diseases
Surveys and Questionnaires
Gene expression
Humans
Lupus Erythematosus, Systemic
Medicine
Secretion
skin and connective tissue diseases
Messenger RNA
Membrane Glycoproteins
business.industry
Biochemistry (medical)
Matrix metalloproteinase 9
Cell Biology
General Medicine
Matrix Metalloproteinase 9
Immunology
Leukocytes, Mononuclear
Female
business
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....8215177a3bb0b57ce08baa126321b1b4