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The new kisspeptin derivative - kissorphin (KSO) - attenuates acute hyperlocomotion and sensitization induced by ethanol and morphine in mice
- Source :
- Alcohol (Fayetteville, N.Y.). 64
- Publication Year :
- 2016
-
Abstract
- Kissorphin (KSO) is a new peptide derived from kisspeptin-10. This peptide possesses neuropeptide FF (NPFF)-like biological activity in vitro ; NPFF, in many cases, inhibits opioid and ethanol effects in rodents. Therefore, the current study explored the influence of KSO on acute ethanol- and morphine-induced hyperactivity, and on the development and expression of locomotor sensitization induced by these drugs. In the present study, sensitization to locomotor effects was induced by repeated exposure to ethanol (2.4 g/kg, intraperitoneally [i.p.], 1 × 4 days) or morphine (10 mg/kg, subcutaneously [s.c.], 1 × 7 days). We found that KSO (1–10 nmol/300 μL, intravenously [i.v.]) did not have an impact on locomotor activity of naive mice. However, it reduced both acute ethanol- (10 nmol/300 μL) and morphine-induced hyperactivity (3 and 10 nmol/300 μL). Pretreatment of animals with KSO (10 nmol/300 μL), before every ethanol or morphine injection during development of sensitization or before the ethanol or morphine challenge, attenuated the development, as well as the expression of locomotor sensitization to both substances. Moreover, prior administration of the NPFF receptor antagonist RF9 (10 nmol/300 μL, i.v.) inhibited the ability of KSO (10 nmol/300 μL) to reduce the expression of ethanol and morphine sensitization. KSO given alone, at all used doses, did not influence the motor coordination measured via the rotarod test. The results from this study show that KSO effectively attenuated acute and repeated effects of ethanol and morphine. Thus, KSO possesses NPFF-like anti-opioid activity in these behavioral studies.
- Subjects :
- Male
Health (social science)
Pharmacology
Toxicology
Biochemistry
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Mice
0302 clinical medicine
medicine
Animals
Neuropeptide FF
Sensitization
Psychomotor Agitation
Kisspeptins
Ethanol
Dose-Response Relationship, Drug
Morphine
Antagonist
Biological activity
General Medicine
030227 psychiatry
Motor coordination
medicine.anatomical_structure
Neurology
chemistry
Opioid
030217 neurology & neurosurgery
Locomotion
medicine.drug
Akathisia, Drug-Induced
Subjects
Details
- ISSN :
- 18736823
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Alcohol (Fayetteville, N.Y.)
- Accession number :
- edsair.doi.dedup.....8213985a34cb11c03dc9fda938636b6d