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Focal Parenchymal Atrophy and Fat Replacement Are Clues for Early Diagnosis of Pancreatic Cancer with Abnormalities of the Main Pancreatic Duct
- Source :
- The Tohoku journal of experimental medicine. 252(1)
- Publication Year :
- 2020
-
Abstract
- Pancreatic cancer is one of the most dangerous solid tumors, but its early diagnosis is difficult. The abnormality of the main pancreatic duct (MPD), such as a single localized stricture and upstream dilatation, might be useful in the early detection of pancreatic cancer. However, these findings are often observed in benign inflammatory cases. This study aimed to clarify whether early pancreatic cancer presenting MPD abnormalities has characteristic features different from those of benign cases. This is a single-center, retrospective study. We analyzed 20 patients who underwent pancreatectomy presenting with a single, localized MPD stricture without identifiable masses on imaging: 10 patients with pancreatic ductal adenocarcinoma (cancer group; 6 with stage 0 and 4 with stage I) and 10 patients with benign strictures (benign group; 8 with inflammation and 2 with low-grade pancreatic intraepithelial neoplasms). Pancreatectomy was performed in these benign cases because high-grade intraepithelial neoplasm was suspected. Although the proportion of patients with diabetes mellitus tended to be higher in the cancer group (6/10) than that in the benign group (1/10) (P = 0.058), other clinical characteristics were not different between the groups. Preoperative cytological malignancies were detected in four patients in the cancer group (4/10) but not in the benign group (P = 0.09). Focal parenchymal atrophy and fat replacement were more frequently detected on computed tomography in the cancer group (7/10) than in the benign group (1/10) (P = 0.02). In conclusion, focal parenchymal atrophy and fat replacement may provide clues for the early diagnosis of pancreatic cancer.
- Subjects :
- Endoscopic ultrasound
Male
medicine.medical_specialty
medicine.medical_treatment
Pancreatic Intraepithelial Neoplasia
Constriction, Pathologic
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Atrophy
Internal medicine
Pancreatic cancer
Medicine
Humans
030212 general & internal medicine
Early Detection of Cancer
Aged
Pancreatic duct
Inflammation
medicine.diagnostic_test
business.industry
Pancreatic Ducts
Cancer
General Medicine
medicine.disease
Prognosis
Pancreatic Neoplasms
medicine.anatomical_structure
030220 oncology & carcinogenesis
Pancreatectomy
Pancreatitis
Female
business
Tomography, X-Ray Computed
Dilatation, Pathologic
Subjects
Details
- ISSN :
- 13493329
- Volume :
- 252
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Tohoku journal of experimental medicine
- Accession number :
- edsair.doi.dedup.....820d28b827fa2148aebfed6733b6c2b6