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Does major depressive disorder change with age?
- Source :
- Psychological medicine. 39(10)
- Publication Year :
- 2009
-
Abstract
- Background The authors used results from a 20-year, high-intensity follow-up to measure the influence of ageing, and of age at onset, on the long-term persistence of symptoms in major depressive disorder (MDD). Method Subjects who completed a 20-year series of semi-annual and then annual assessments with a stable diagnosis of MDD or schizo-affective disorder other than mainly schizophrenic (n=220) were divided according to their ages at intake into youngest (18-29 years), middle (30-44 years) and oldest (>45 years) groups. Depressive morbidity was quantified as the proportion of weeks spent in major depressive or schizo-affective episodes. General linear models then tested for effects of time and time x group interactions on these measures. Regression analyses compared the influence of age of onset and of current age. Results Analyses revealed no significant time or group x time effects on the proportions of weeks in major depressive episodes in any of the three age groups. Earlier ages of onset were associated with greater symptom persistence, particularly in the youngest group. The proportions of weeks ill showed intra-individual stability over time that was most evident in the oldest group. Conclusions These results indicate that the persistence of depressive symptoms in MDD does not change as individuals move from their third to their fifth decade, from their fourth to their sixth decade, or from their sixth to their eighth decade. An early age of onset, rather than youth per se, is associated with greater morbidity over two decades.
- Subjects :
- Persistence (psychology)
Adult
Male
medicine.medical_specialty
Aging
Adolescent
Article
Young Adult
Sex Factors
medicine
Humans
Young adult
Age of Onset
Psychiatry
Applied Psychology
Depression (differential diagnoses)
Aged
Psychiatric Status Rating Scales
Depressive Disorder, Major
Social environment
Middle Aged
medicine.disease
Psychiatry and Mental health
Ageing
Symptom persistence
Major depressive disorder
Female
Age of onset
Psychology
Demography
Subjects
Details
- ISSN :
- 14698978
- Volume :
- 39
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Psychological medicine
- Accession number :
- edsair.doi.dedup.....81f559a94a63a1ac524864b148d94b5b