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Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal
- Source :
- eLife, eLife, eLife Sciences Publication, 2017, 6, ⟨10.7554/611619131⟩, eLife, 2017, 6, ⟨10.7554/611619131⟩, eLife (6), . (2017), eLife, Vol 6 (2017)
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells. However, its level fluctuates in each of these cells. If ATML1 levels surpass a threshold during the G2 phase of the cell cycle, the cell will likely enter a state of endoreduplication and become giant. Otherwise, the cell divides. Our results demonstrate a fluctuation-driven patterning mechanism for how cell fate decisions can be initiated through a random yet tightly regulated process.
- Subjects :
- 0301 basic medicine
Cell type
QH301-705.5
Science
[SDV]Life Sciences [q-bio]
Cell fate determination
Biology
General Biochemistry, Genetics and Molecular Biology
endoreduplication
modelling
03 medical and health sciences
sepal
pattern formation
Live cell imaging
Arabidopsis
transcription factors
Botany
Endoreduplication
giant cell
Biology (General)
Transcription factor
cell fate specification
ATML1
modélisation
General Immunology and Microbiology
cellule epidermique
fluctuation
General Neuroscience
arabidopsis thaliana
General Medicine
Cell cycle
biology.organism_classification
Cell biology
030104 developmental biology
Giant cell
Medicine
facteur de transcription
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Database :
- OpenAIRE
- Journal :
- eLife, eLife, eLife Sciences Publication, 2017, 6, ⟨10.7554/611619131⟩, eLife, 2017, 6, ⟨10.7554/611619131⟩, eLife (6), . (2017), eLife, Vol 6 (2017)
- Accession number :
- edsair.doi.dedup.....81f35eb3aae6b6de6fa9f18b3facda71