Back to Search
Start Over
Erythrocyte cation content, globin chain synthesis and glucose metabolism in dysmyelopoietic syndromes
- Source :
- Acta haematologica. 68(2)
- Publication Year :
- 1982
-
Abstract
- Red blood cells (RBC) from 13 patients suffering from dysmyelopoietic syndromes (DMPS) have been studied. About half of these subjects showed an abnormal Na+ and K+ leakage of their RBC, which were incubated at 37 degrees C for 24 h. The mean rate of the glycolytic pathway increased significantly and the glycolysis values correlated well with the Na+ gain. Moreover, 9 out of the 13 patients showed an abnormal biosynthetic ratio of haemoglobin chains in their reticulocytes. Since the multiple defects in DMPS erythrocytes do not seem clearly linked by cause-effect relationships, they probably derive from several cooperating factors in pathological erythroid precursors, leading to RBC membrane damage.
- Subjects :
- Ineffective erythropoiesis
Blood Glucose
Male
Erythrocytes
Reticulocytes
Carbohydrate metabolism
Biology
medicine.disease_cause
medicine
Humans
Erythropoiesis
Bone Marrow Diseases
Aged
Dysmyelopoietic Syndromes
Sodium
Anemia, Aplastic
Globin chain
Hematology
General Medicine
Syndrome
Middle Aged
Red cell membrane
Anemia, Sideroblastic
Globins
Biochemistry
Potassium
Thalassemia
Female
Subjects
Details
- ISSN :
- 00015792
- Volume :
- 68
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta haematologica
- Accession number :
- edsair.doi.dedup.....81efef33f98f979caef714a140135063