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Effect of Pharmacological Modulation of Activity of Metabotropic Glutamate Receptors on Their Gene Expression after Excitotoxic Damage in Hippocampal Neurons
- Source :
- Bulletin of Experimental Biology and Medicine. 162:784-787
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Microinjection of kainic acid into rat hippocampus causes excitotoxic neuronal damage predominantly in the CA3 and CA1 fields. These lesions can be significantly reduced by simultaneous administration of MPEP, a negative allosteric modulator of type 5 metabotropic glutamate receptors, and LY354740, an agonist of type 2 metabotropic glutamate receptors. The decrease in neuronal death in the hippocampus during pharmacological modulation was paralleled by adaptive changes in gene expression. In the hippocampus, gene expression of type 5 postsynaptic metabotropic glutamate receptor was close to the control level, and in the frontal cortex expression of the gene of α1-subunit of the GABAA receptor returned to normal. In the frontal cortex, a reciprocal relationship was observed for type 2 metabotropic glutamate receptor: expression of the corresponding gene decreased in response to pharmacological activation.
- Subjects :
- Male
0301 basic medicine
Pyridines
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate
Hippocampus
General Biochemistry, Genetics and Molecular Biology
Stereotaxic Techniques
Bridged Bicyclo Compounds
03 medical and health sciences
0302 clinical medicine
Seizures
Excitatory Amino Acid Agonists
Animals
Rats, Wistar
Neurons
Metabotropic glutamate receptor 8
Kainic Acid
Chemistry
Metabotropic glutamate receptor 5
Metabotropic glutamate receptor 4
Metabotropic glutamate receptor 7
Metabotropic glutamate receptor 6
General Medicine
Receptors, GABA-A
Frontal Lobe
Rats
030104 developmental biology
Gene Expression Regulation
nervous system
Organ Specificity
Metabotropic glutamate receptor
Metabotropic glutamate receptor 1
Metabotropic glutamate receptor 3
Excitatory Amino Acid Antagonists
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15738221 and 00074888
- Volume :
- 162
- Database :
- OpenAIRE
- Journal :
- Bulletin of Experimental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....81e787a20b7562b7dce50510bacf0dbc