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Organ Function Preservation Failure after (Chemo)Radiotherapy in Head and Neck Cancer: A Retrospective Cohort Analysis
- Source :
- Otolaryngology-head and neck surgery, 161(2), 288-296. Mosby Inc., Otolaryngology-Head and Neck Surgery, 161(2), 288-296. SAGE PUBLICATIONS LTD
- Publication Year :
- 2019
-
Abstract
- Objective: The aim of the current study was to determine the incidence of organ function preservation failure (OFPF) in patients with head and neck squamous cell carcinoma (HNSCC) treated by (chemo)radiotherapy and to identify its risk factors. Study Design: Retrospective cohort analysis. Setting: Tertiary cancer care center. Subjects and Methods: A single-center retrospective cohort analysis was done (n = 703) in which OFPF after (chemo)radiotherapy was assessed. OFPF was defined as local failure or pure functional failure in the absence of local failure because of major surgical intervention (total laryngectomy, commando resection, permanent tracheostomy) or feeding tube dependence >2 years. Results: OFPF occurred in 153 patients (21.8%). Reasons for OFPF were local failure in 103 patients (14.6%) and functional failure in 50 patients (7.2%). Evidence of functional failure included need for total laryngectomy (n = 9, 1.3%), commando resection (n = 2, 0.3%), permanent tracheostomy (n = 16, 2.3%), and/or long-term feeding tube for functional reasons (n = 23, 3.3%). In a Cox proportional hazards model, OFPF was worse for patients with T4 tumors (hazard ratio [HR]
- Subjects :
- Adult
Male
medicine.medical_specialty
Functional failure
Organ function
Laryngectomy
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Tracheostomy
Risk Factors
medicine
functional failure
Humans
In patient
Treatment Failure
030223 otorhinolaryngology
chemoradiation
Laryngeal Neoplasms
Aged
Retrospective Studies
Aged, 80 and over
Chemo-radiotherapy
Hypopharyngeal Neoplasms
organ function preservation
business.industry
Incidence (epidemiology)
Head and neck cancer
toxicity
Retrospective cohort study
Chemoradiotherapy
Middle Aged
medicine.disease
Head and neck squamous-cell carcinoma
Oropharyngeal Neoplasms
Otorhinolaryngology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Surgery
Female
head and neck cancer
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 01945998
- Volume :
- 161
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Otolaryngology-head and neck surgery
- Accession number :
- edsair.doi.dedup.....81e63b44f0ed3f924ebdeafcbdab1750