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Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population

Authors :
John Wei
Svetlana Frenkel
Wenxin Jiang
Pingzhao Hu
Stephen W. Scherer
Yong Won Jin
Charles N. Bernstein
Michael Sargent
Bhooma Thiruvahindrapuram
Qin Kuang
Source :
Data in Brief, Vol 25, Iss, Pp-(2019), Data in Brief
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals with Inflammatory Bowel Disease (IBD). The CNV data was obtained by using multiple quality control measures and merging the results of three different CNV detection algorithms: PennCNV, iPattern, and QuantiSNP. The final dataset contains 4,402 CNVs detected by two or three algorithms independently with high confidence. This paper provides a detailed description of the data generation and quality control steps. For further interpretation of the data presented in this article, please see the research article entitled 'Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease'.

Details

Language :
English
ISSN :
23523409
Volume :
25
Database :
OpenAIRE
Journal :
Data in Brief
Accession number :
edsair.doi.dedup.....81defdc6c8d28424dfdbe2b13877c24e