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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
- Source :
- Nature genetics. 40(1)
- Publication Year :
- 2008
-
Abstract
- We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
- Subjects :
- Adenoma
Genetics
Chromosomes, Human, Pair 15
education.field_of_study
Colorectal cancer
Population
Chromosome
Cancer
Genome-wide association study
Locus (genetics)
Single-nucleotide polymorphism
Biology
medicine.disease
Polymorphism, Single Nucleotide
Chromosome 15
Cell Line, Tumor
Jews
medicine
Humans
Genetic Predisposition to Disease
Colorectal Neoplasms
education
Cells, Cultured
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Volume :
- 40
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....81dc7254dbabfbc35a21ffe2428734b3