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Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis
- Source :
- Neural Regeneration Research, Vol 12, Iss 6, Pp 953-958 (2017)
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Medknow Publications, 2017.
-
Abstract
- Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that ganoderma lucidum polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
biology
nerve regeneration
brain injury
H2O2
cerebellar granule cells
Bim
Bax
Bcl-2
cytochrome C
caspase-3
neural regeneration
Cytochrome c
Caspase 3
Oxidative phosphorylation
Polysaccharide
medicine.disease
medicine.disease_cause
Neuroprotection
lcsh:RC346-429
Cell biology
03 medical and health sciences
030104 developmental biology
Developmental Neuroscience
chemistry
Apoptosis
biology.protein
medicine
Reperfusion injury
Oxidative stress
lcsh:Neurology. Diseases of the nervous system
Subjects
Details
- Language :
- English
- ISSN :
- 16735374
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Neural Regeneration Research
- Accession number :
- edsair.doi.dedup.....81d18692cb55fc0bc055a08df97b6ee1