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Improved Diagnostic Performance of High-Sensitivity Cardiac Troponin Assays Is an Artifact of Censored Data
- Source :
- Clinical Chemistry. 62:1654-1657
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- BACKGROUND High-sensitivity cardiac troponin assays with improved analytical performance at low concentrations are credited with increased diagnostic sensitivity in acute coronary syndrome patients. We investigated the relationship between analytical sensitivity (detection capability) and diagnostic accuracy and tested the effect of censoring data with a software model. METHOD We generated 4 sets of results with decreasing detection capability and compared the ROC curves with and without censored data. RESULTS There was no relationship between diagnostic performance and detection capability. When data were censored the diagnostic accuracy decreased progressively with an increase in the threshold concentration for censoring. The ROC curves constructed with censored data have a characteristic appearance with a straight line between the censoring point and the top right hand corner. CONCLUSIONS There is not a direct relationship between the diagnostic accuracy and the detection capability of cardiac troponin assays. The artifactual decrease in diagnostic accuracy can be added to the list of reasons why data should not be censored and this practice should be disclosed in studies on diagnostic accuracy.
- Subjects :
- medicine.medical_specialty
Cardiac troponin
Receiver operating characteristic
business.industry
Biochemistry (medical)
Clinical Biochemistry
Diagnostic accuracy
030204 cardiovascular system & hematology
Censoring (statistics)
Troponin
03 medical and health sciences
0302 clinical medicine
ROC Curve
Internal medicine
Cardiology
Humans
Medicine
030212 general & internal medicine
Acute Coronary Syndrome
business
Software
Volume concentration
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi.dedup.....81c46db7455a0221a543a17ac70b8442