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Histological grading of ovarian mucinous carcinoma – an outcome‐based analysis of traditional and novel systems
- Source :
- Histopathology. 77:26-34
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- AIMS Grading of primary ovarian mucinous carcinoma (OMC) is inconsistent among practices. The International Collaboration on Cancer Reporting recommends grading OMC using the International Federation of Gynecology and Obstetrics (FIGO) system for endometrial endometrioid carcinoma, when needed. The growth pattern (expansile versus infiltrative), a known prognostic variable in OMC, is not considered in any grading system. We herein analysed the prognostic value of various grading methods in a well-annotated cohort of OMC. METHODS AND RESULTS Institutional OMCs underwent review and grading by the Silverberg and FIGO schemes and a novel system, growth-based grading (GBG), defined as G1 (expansile growth or infiltrative invasion in ≤10%) and G2 (infiltrative growth >10% of tumour). Of 46 OMCs included, 80% were FIGO stage I, 11% stage II and 9% stage III. On follow-up (mean = 52 months, range = 1-190), five patients (11%) had adverse events (three recurrences and four deaths). On univariate analysis, stage (P = 0.01, Cox proportional analysis), Silverberg grade (P = 0.01), GBG grade (P = 0.001) and percentage of infiltrative growth (P
- Subjects :
- Adult
0301 basic medicine
Oncology
medicine.medical_specialty
Prognostic variable
Histology
Multivariate analysis
Adolescent
Carcinoma, Ovarian Epithelial
Pathology and Forensic Medicine
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Humans
Ovarian Mucinous Carcinoma
Adverse effect
Grading (education)
Aged
Aged, 80 and over
Univariate analysis
business.industry
General Medicine
Middle Aged
medicine.disease
Adenocarcinoma, Mucinous
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Female
Neoplasm Grading
business
Subjects
Details
- ISSN :
- 13652559 and 03090167
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....81bccc661298774073518a496cdf15e7