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Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera
- Publication Year :
- 2016
-
Abstract
- Eight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-1-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity.
- Subjects :
- 0301 basic medicine
Antifungal
Antifungal Agents
Stereochemistry
medicine.drug_class
Plant Science
Microbial Sensitivity Tests
Horticulture
Biology
Biochemistry
Strobilurin G
Terpene
03 medical and health sciences
medicine
Hydrocarbons, Chlorinated
Humans
Molecular Biology
Mycelium
Mycenaceae
Benzofurans
Favolaschia calocera
Basidiomycota
General Medicine
Strobilurins
biology.organism_classification
Kenya
Triterpenes
030104 developmental biology
Pterulinic acid
Oxepins
Fatty Acids, Unsaturated
Methacrylates
Drug Screening Assays, Antitumor
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....81b157e4673f176c61b3a1a96f2a18ff