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Molecular characterization of new emerging sub-genotype VIIh Newcastle disease viruses in China
- Source :
- Virus Genes. 55:314-321
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Newcastle disease (ND) has been enzootic in China for several decades since the first recognition of the disease in 1946 in China. Continuous surveillance revealed that the sub-genotype VIId Newcastle disease virus (NDV) has been predominantly responsible for most of ND outbreak in China in recent years. But in the present study, three virulent NDVs isolated from poultry in southern China were classified as sub-genotype VIIh, which is highly related to the viruses circulating in some Southeast Asia countries. Continuous isolation of genotype VIIh NDV strains in the region suggests its panzootic potential. This is the first report of the sub-genotype VIIh NDVs in domestic poultry in China. The complete genome length of the three isolates was 15,192 nucleotides, and the motif at the cleavage site of F protein was 112RRRRR/F117 or 112RRRKR/F117, which was typical of virulent NDV. Phylogenetic analysis based on the F gene revealed that the three viruses had close relationship with the sub-genotype VIIh virus isolated from wild bird in 2011 in China. These viruses might have formed a stable lineage in poultry during 2012–2016 and have the potential to cause enzootic in China. Our study revealed the genetic and phylogenetic characteristics of the three sub-genotype VIIh isolates, which could help us to better understand the epidemiological context of these viruses.
- Subjects :
- China
Genotype
Newcastle Disease
Newcastle disease virus
Virulence
Biology
Newcastle disease
Poultry
Virus
Disease Outbreaks
03 medical and health sciences
Zoonoses
Virology
Genetics
Animals
Humans
Molecular Biology
Phylogeny
Poultry Diseases
Panzootic
030304 developmental biology
0303 health sciences
Phylogenetic tree
030306 microbiology
Outbreak
General Medicine
biology.organism_classification
RNA, Viral
Enzootic
Chickens
Subjects
Details
- ISSN :
- 1572994X and 09208569
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Virus Genes
- Accession number :
- edsair.doi.dedup.....81a95d728fe5b58e58c3b212cf7f0143