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Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
- Source :
- OncoImmunology, OncoImmunology, Taylor & Francis, 2012, 1 (3), pp.380-382. ⟨10.4161/onci.18801⟩, Oncoimmunology
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
- Subjects :
- Pathology
medicine.medical_specialty
immune tolerance
Immunology
[SDV.CAN]Life Sciences [q-bio]/Cancer
Plasmacytoid dendritic cell
macromolecular substances
Flow cytometry
Immune tolerance
medicine
plasmacytoid dendritic cell
Immunology and Allergy
Progression-free survival
Author's View
medicine.diagnostic_test
business.industry
Cancer
hemic and immune systems
medicine.disease
Epithelium
3. Good health
medicine.anatomical_structure
ovarian cancer
Oncology
Immunohistochemistry
prognosis
Ovarian cancer
business
progression-free survival
Subjects
Details
- Language :
- English
- ISSN :
- 21624011 and 2162402X
- Database :
- OpenAIRE
- Journal :
- OncoImmunology, OncoImmunology, Taylor & Francis, 2012, 1 (3), pp.380-382. ⟨10.4161/onci.18801⟩, Oncoimmunology
- Accession number :
- edsair.doi.dedup.....81a6c9b1faf27b87b68dead13b2e9add