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Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
- Source :
- The Journal of clinical investigation
- Publication Year :
- 2011
-
Abstract
- Atopic asthma is a chronic disease of the airways that has taken on epidemic proportions in the industrialized world. The increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach, from Western societies. In this study, we have utilized mouse models of allergic airway disease induced by ovalbumin or house dust mite allergen to experimentally examine a possible inverse correlation between H. pylori and asthma. H. pylori infection efficiently protected mice from airway hyperresponsiveness, tissue inflammation, and goblet cell metaplasia, which are hallmarks of asthma, and prevented allergen-induced pulmonary and bronchoalveolar infiltration with eosinophils, Th2 cells, and Th17 cells. Protection against asthma was most robust in mice infected neonatally and was abrogated by antibiotic eradication of H. pylori. Asthma protection was further associated with impaired maturation of lung-infiltrating dendritic cells and the accumulation of highly suppressive Tregs in the lungs. Systemic Treg depletion abolished asthma protection; conversely, the adoptive transfer of purified Treg populations was sufficient to transfer protection from infected donor mice to uninfected recipients. Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma.
- Subjects :
- Adoptive cell transfer
2700 General Medicine
10263 Institute of Experimental Immunology
Bronchoalveolar Lavage
T-Lymphocytes, Regulatory
Mice
0302 clinical medicine
immune system diseases
Lung
0303 health sciences
biology
medicine.diagnostic_test
Brief Report
10061 Institute of Molecular Cancer Research
General Medicine
respiratory system
3. Good health
medicine.anatomical_structure
030211 gastroenterology & hepatology
medicine.symptom
610 Medicine & health
Inflammation
Helicobacter Infections
03 medical and health sciences
Th2 Cells
Hypersensitivity
medicine
Animals
030304 developmental biology
Asthma
Goblet cell
Helicobacter pylori
business.industry
Dendritic Cells
biology.organism_classification
medicine.disease
respiratory tract diseases
Mice, Inbred C57BL
Disease Models, Animal
Ovalbumin
Bronchoalveolar lavage
Immunology
biology.protein
Th17 Cells
570 Life sciences
business
Subjects
Details
- Volume :
- 121
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical investigation
- Accession number :
- edsair.doi.dedup.....81864d4143a86be544a712f3c5bb3039
- Full Text :
- https://doi.org/10.1172/JCI45041