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Functional Graphene Oxide Nanocarriers for Drug Delivery

Authors :
Jialing Xu
Xincheng Mao
Xiaohong Hu
Jingyang Kong
Yuanfeng Ye
Source :
International Journal of Polymer Science, Vol 2019 (2019)
Publication Year :
2019
Publisher :
Hindawi, 2019.

Abstract

The family of graphene has attracted increasing attention on account of their large specific surface area and good mechanical properties in the biomedical field. However, some characteristics like targeted delivery property and drug delivery capacity could not satisfy the need of a drug carrier. Herein, a graphene oxide (GO) nanocarrier was designed by modification of a folic acid (FA) derivative and a β-cyclodextrin (β-CD) derivative in order to improve two properties, respectively. In the first step, reactive or crosslinkable FA and aldehydic β-CD (β-CD-CHO) were designed and synthesized for further modification. In the second step, synthesized functional molecules were coupled onto GO sheets one by one to obtain the GO nanocarrier. IR spectra and XRD results were used to identify the chemical and structural information before and after modification for the GO nanocarrier. The final GO nanocarrier exhibited a typical thin wrinkled sheet morphology of the GO sheet without any influence by two functional molecules. Finally, in vitro evaluation was used to clarify the drug loading and controlling capacity of the nanocarrier as a drug delivery system. The results revealed that the GO nanocarrier had a better CPT loading capacity and showed better controllability for CPT release.

Details

Language :
English
ISSN :
16879422
Database :
OpenAIRE
Journal :
International Journal of Polymer Science
Accession number :
edsair.doi.dedup.....8178b6764afadc05b338f841661e9712
Full Text :
https://doi.org/10.1155/2019/8453493