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Multicentre, Prospective Observational Study of Pegfilgrastim Primary Prophylaxis in Patients at High Risk of Febrile Neutropenia in Poland : pROFIL Study
- Source :
- Contemporary Oncology
- Publication Year :
- 2015
-
Abstract
- Aim of the study PROFIL was a prospective observational study conducted to investigate physicians’ evaluation of febrile neutropenia (FN) risk and reasons for giving pegfilgrastim primary prophylaxis (PP) in routine clinical practice in Poland. Material and methods Adult cancer patients treated with chemotherapy (CT), assessed by investigators as having high overall FN risk, and who received pegfilgrastim in cycle 1 were enrolled between 03/2009 and 09/2010. Investigators assessed FN risk of the CT regimen, individual risk factors, and overall FN risk, and were asked to provide the most important reasons for providing pegfilgrastim PP. Investigator-assessed CT FN risk was compared with guideline classification. Results Data were analysed from 1006 breast, ovarian, and lung cancer, and non-Hodgkin (NHL) and Hodgkin lymphoma (HL) patients. The most important reasons for using pegfilgrastim PP were high CT FN risk and advanced disease; these were consistent across tumour types and treatment intent. The investigators generally assessed high CT FN risk in agreement with guideline classification. Febrile neutropenia occurred in 4% of patients, most commonly in HL, NHL, and patients with advanced disease. Conclusions High CT FN risk and advanced stage of disease were found to be the most important reasons for providing pegfilgrastim PP by physicians in Poland.
- Subjects :
- Original Paper
Pediatrics
medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
Cancer
Guideline
GCSF
chemotherapy
medicine.disease
pegfilgrastim
Regimen
febrile neutropenia
Oncology
risk category
medicine
Radiology, Nuclear Medicine and imaging
Observational study
Lung cancer
business
Febrile neutropenia
Pegfilgrastim
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Contemporary Oncology
- Accession number :
- edsair.doi.dedup.....817471eee2fc0ffcb57a89b0d6ecb62a