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Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, BioMed Central, 2020, 20 (1), pp.384. ⟨10.1186/s12879-020-05098-0⟩, BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-7 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background A particular ability of the Staphylococcus aureus clonal complex 398 (CC398) to cause bone and joint infections (BJI) remains questionable, since some studies have described high prevalence of MSSA CC398 in prosthetic joint infection (PJI) and diabetic foot ostemolyelitis (DFO). Here, we described the long-term epidemiology of CC398 among S. aureus isolated from BJI and identified risk factors associated with CC398. Methods We included all bone and joint samples with S. aureus-positive culture in our university hospital between January 2010 and December 2017. Logistic regression was used for univariate and multivariate analysis. Results We identified 124 CC398 isolates among the 958 BJI-associated S. aureus. The proportion of CC398 among S. aureus increased steadily from 4% in 2010 to 26% in 2017. Only 4 isolates of CC398 were resistant to methicillin. The distribution of BJI types due to CC398 and non CC398 isolates was similar. In multivariate analysis, age (p = 0.034, OR = 3.9), McCabe score (p = 0.005, OR = 5) and inoculation mechanism (p = 0.020, OR = 3.7) were associated with PJI-related CC398. The year of infection (p p = 0.001, OR = 1.5) and grade 4 (severe) of the International Working Group of the Diabetic Foot classification (p Conclusion We highlighted here the emergence and spread of CC398-MSSA in BJI. Patients with comorbidities are at high risk of CC398 MSSA PJI and DFO. The spread of CC398 in the community and hospital settings remains unclear and further epidemiological studies are needed to identify the determinants of its success.
- Subjects :
- Male
0301 basic medicine
Prosthetic joint infection
Multivariate analysis
MESH: Comorbidity
Comorbidity
medicine.disease_cause
Logistic regression
Polymerase Chain Reaction
Hospitals, University
MESH: Aged, 80 and over
Medical microbiology
Risk Factors
MESH: Risk Factors
Bone joint infection
Diabetic foot infection
Epidemiology
Prevalence
Aged, 80 and over
MESH: Aged
MESH: Middle Aged
Osteomyelitis
Middle Aged
Staphylococcal Infections
Diabetic Foot
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
Staphylococcus aureus
MESH: Arthritis, Infectious
MESH: Communicable Diseases
Female
Research Article
Adult
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
030106 microbiology
MESH: Staphylococcal Infections
MESH: Methicillin-Resistant Staphylococcus aureus
Communicable Diseases
MESH: Osteomyelitis
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Internal medicine
MESH: Diabetic Foot
medicine
Humans
lcsh:RC109-216
Human ST398
MESH: Prevalence
Aged
Retrospective Studies
MESH: Hospitals, University
Arthritis, Infectious
MESH: Humans
business.industry
MESH: Adult
MESH: Polymerase Chain Reaction
MESH: Retrospective Studies
medicine.disease
Diabetic foot
MESH: Male
030104 developmental biology
CC398
Tropical medicine
Methicillin susceptible Staphylococcus aureus
Methicillin Susceptible Staphylococcus Aureus
business
MESH: Female
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- ISSN :
- 14712334
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....816da1df1471e04fa339fc61a546443a