Back to Search
Start Over
Maternal plasma soluble neuropilin-1 is downregulated in fetal growth restriction complicated by abnormal umbilical artery Doppler: a pilot study
- Source :
- Ultrasound in Obstetrics & Gynecology
- Publication Year :
- 2021
-
Abstract
- Objectives Placental expression of neuropilin‐1 (NRP1), a proangiogenic member of the vascular endothelial growth factor receptor family involved in sprouting angiogenesis, was recently discovered to be downregulated in pregnancies with fetal growth restriction (FGR) and abnormal umbilical artery (UA) Doppler. Soluble NRP1 (sNRP1) is an antagonist to NRP1; however, little is known about its role in normal and FGR pregnancies. This study tested the hypotheses that, first, sNRP1 would be detectable in maternal circulation and, second, its concentration would be upregulated in FGR pregnancies compared to those with normal fetal growth and this would correlate with the severity of the disease as assessed by UA Doppler. Methods This was a prospective case–control pilot study of 40 singleton pregnancies (20 FGR cases and 20 uncomplicated controls) between 24 + 0 and 40 + 0 weeks' gestation followed in an academic perinatal center from January 2015 to May 2017. FGR was defined as an ultrasound‐estimated fetal weight
- Subjects :
- Adult
medicine.medical_specialty
soluble neuropilin‐1
Biometry
Placenta
placental angiogenesis
Diastole
Down-Regulation
Gestational Age
Pilot Projects
Severity of Illness Index
Ultrasonography, Prenatal
Umbilical Arteries
fetal growth restriction
Obstetrics and gynaecology
Pregnancy
medicine.artery
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Placental Circulation
Prospective Studies
Sprouting angiogenesis
Fetus
Original Paper
Fetal Growth Retardation
umbilical artery Doppler
Radiological and Ultrasound Technology
business.industry
Obstetrics
Infant, Newborn
Obstetrics and Gynecology
Gestational age
Umbilical artery
Ultrasonography, Doppler
General Medicine
Original Papers
Neuropilin-1
Reproductive Medicine
Fetal Weight
Case-Control Studies
Circulatory system
Infant, Small for Gestational Age
Gestation
Female
neuropilin‐1
business
Subjects
Details
- ISSN :
- 14690705
- Volume :
- 58
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Ultrasound in obstetricsgynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....81658416879028e0255637d2787fe95c