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Liver graft outcomes from donors with vaccine induced thrombosis and thrombocytopenia (VITT): United Kingdom multicenter experience
- Source :
- American Journal of Transplantation. 22:996-998
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Vaccine-induced immune thrombosis and thrombocytopenia (VITT) syndrome is a new entity, characterised by severe thrombocytopenia and multiple sites of thrombosis1 . The presumed mechanism is driven by anti-platelet factor 4 (PF4) antibodies causing platelet activation1 . Donors with VITT syndrome have a particular relevance for liver transplantation (LT), due to the associated risk of passenger lymphocyte syndrome, and a predisposition for porto-mesenteric or hepatic vein thrombosis2 .
- Subjects :
- medicine.medical_specialty
Tissue and Organ Procurement
Lymphocyte
medicine.medical_treatment
Liver transplantation
medicine.disease_cause
Gastroenterology
Autoimmunity
Internal medicine
medicine
Humans
Immunology and Allergy
Pharmacology (medical)
Platelet
Vein
Vaccines
Transplantation
biology
business.industry
Graft Survival
Thrombosis
medicine.disease
Thrombocytopenia
Tissue Donors
medicine.anatomical_structure
Liver
biology.protein
Antibody
business
Platelet factor 4
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- American Journal of Transplantation
- Accession number :
- edsair.doi.dedup.....815b4eed23b1c4d8e5905fd94a0a083e