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Neuroendocrine differentiation in usual‐type prostatic adenocarcinoma: Molecular characterization and clinical significance
- Source :
- Prostate
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND Small cell neuroendocrine (NE) carcinomas of the prostate classically lose androgen receptor (AR) expression, may harbor loss of the RB1, TP53, and PTEN tumor suppressor genes, and are associated with a poor prognosis. However usual-type adenocarcinomas may also contain areas of NE differentiation, and in this context the molecular features and biological significance are less certain. METHODS We examined the molecular phenotype and oncologic outcomes of primary prostate adenocarcinomas with ≥5% NE differentiation (≥5% chromogranin A-positive NE cells in any given tumor spot on tissue microarray) using three independent study sets: a set of tumors with paneth cell-like NE differentiation (n = 26), a retrospective case-cohort of intermediate- and high-risk patients enriched for adverse outcomes (n = 267), and primary tumors from a retrospective series of men with eventual castration-resistant metastatic prostate cancer (CRPC) treated with abiraterone or enzalutamide (n = 55). RESULTS Benign NE cells expressed significantly lower quantified AR levels compared with paired benign luminal cells (P
- Subjects :
- Male
0301 basic medicine
Ubiquitin-Protein Ligases
Urology
Adenocarcinoma
Neuroendocrine differentiation
Article
Metastasis
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
Prostate cancer
0302 clinical medicine
Neuroendocrine Cells
medicine
Carcinoma
Humans
Enzalutamide
PTEN
Carcinoma, Small Cell
Retrospective Studies
biology
business.industry
PTEN Phosphohydrolase
Prostatic Neoplasms
Chromogranin A
Cell Differentiation
Middle Aged
medicine.disease
Immunohistochemistry
Neuroendocrine Tumors
Prostatic Neoplasms, Castration-Resistant
Retinoblastoma Binding Proteins
030104 developmental biology
Oncology
chemistry
Receptors, Androgen
030220 oncology & carcinogenesis
biology.protein
Cancer research
Tumor Suppressor Protein p53
business
Signal Transduction
Subjects
Details
- ISSN :
- 10970045 and 02704137
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- The Prostate
- Accession number :
- edsair.doi.dedup.....8142c179aafca5494bfa53c7bbca5d5c