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The influence of dopaminergic polymorphisms on selective stopping
- Source :
- Behavioural brain research. 381
- Publication Year :
- 2019
-
Abstract
- Although the genetic influence on global stopping has been extensively investigated, little is known about the genetic contribution to other more complex forms of inhibitory control such as selective stopping. The selectivity of inhibitory control can be assessed by using the stimulus-selective stop-signal task. Notably, recent behavioural and neural evidence indicates that individuals can adopt selective but also non-selective stopping strategies to solve it. This study aimed to investigate for the first time the influence of two relevant dopaminergic polymorphisms (in COMT and DRD2 genes) on stimulus-selective stopping in a sample of 529 adults. Results showed that although none of these polymorphisms (neither individually nor in combination) modulate the latency of the stop process in each strategy (the stop-signal reaction time), the choice of strategy was influenced by their interaction. These results suggest that dopaminergic polymorphisms might influence strategy adoption in selective stopping paradigms, which constitutes a novel finding.
- Subjects :
- Male
0303 health sciences
Adolescent
Receptors, Dopamine D2
Dopaminergic
Genetics, Behavioral
Biology
Catechol O-Methyltransferase
Polymorphism, Single Nucleotide
03 medical and health sciences
Behavioral Neuroscience
Inhibition, Psychological
Young Adult
0302 clinical medicine
Inhibitory control
Reaction Time
Humans
Female
Latency (engineering)
Neuroscience
030217 neurology & neurosurgery
Response inhibition
030304 developmental biology
Subjects
Details
- ISSN :
- 18727549
- Volume :
- 381
- Database :
- OpenAIRE
- Journal :
- Behavioural brain research
- Accession number :
- edsair.doi.dedup.....813e181800244db51302cd44206008f0