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The influence of dopaminergic polymorphisms on selective stopping

Authors :
Jacobo Albert
Kora-Mareen Bühler
Irene Rincón-Pérez
Alberto J. Sánchez-Carmona
José Antonio López-Moreno
Victor Echeverry-Alzate
José A. Hinojosa
Source :
Behavioural brain research. 381
Publication Year :
2019

Abstract

Although the genetic influence on global stopping has been extensively investigated, little is known about the genetic contribution to other more complex forms of inhibitory control such as selective stopping. The selectivity of inhibitory control can be assessed by using the stimulus-selective stop-signal task. Notably, recent behavioural and neural evidence indicates that individuals can adopt selective but also non-selective stopping strategies to solve it. This study aimed to investigate for the first time the influence of two relevant dopaminergic polymorphisms (in COMT and DRD2 genes) on stimulus-selective stopping in a sample of 529 adults. Results showed that although none of these polymorphisms (neither individually nor in combination) modulate the latency of the stop process in each strategy (the stop-signal reaction time), the choice of strategy was influenced by their interaction. These results suggest that dopaminergic polymorphisms might influence strategy adoption in selective stopping paradigms, which constitutes a novel finding.

Details

ISSN :
18727549
Volume :
381
Database :
OpenAIRE
Journal :
Behavioural brain research
Accession number :
edsair.doi.dedup.....813e181800244db51302cd44206008f0