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Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells
- Source :
- Molecular Brain, Molecular Brain, Vol 13, Iss 1, Pp 1-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However, while there are many subtypes of NPCs with different regional identities, the subtype of iPSC-derived NPCs that is most appropriate for cell therapy for SCI has not been identified. Here, we generated forebrain- and spinal cord-type NPCs from human iPSCs and grafted them onto the injured spinal cord in mice. These two types of NPCs retained their regional identities after transplantation and exhibited different graft-host interconnection properties. NPCs with spinal cord regional identity but not those with forebrain identity resulted in functional improvement in SCI mice, especially in those with mild-to-moderate lesions. This study highlights the importance of the regional identity of human iPSC-derived NPCs used in cell therapy for SCI.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Mice, SCID
Spinal cord injury
Motor Activity
Biology
lcsh:RC346-429
Cell Line
Cell therapy
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Neural Stem Cells
Mice, Inbred NOD
otorhinolaryngologic diseases
medicine
Animals
Humans
Induced pluripotent stem cell
Region-specific neural progenitors
Molecular Biology
lcsh:Neurology. Diseases of the nervous system
Spinal Cord Injuries
Stem cell therapy
Behavior, Animal
Research
Cell Differentiation
Recovery of Function
Stem-cell therapy
Spinal cord
medicine.disease
Neural stem cell
Transplantation
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Spinal Cord
Organ Specificity
Forebrain
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17566606
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Molecular Brain
- Accession number :
- edsair.doi.dedup.....81386c516eb031358ff60840115c62e0