Back to Search
Start Over
Expression of angiopoietin-2 gene and its receptor Tie2 in hepatocellular carcinoma
- Source :
- Scopus-Elsevier
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology of hepatocellular carcinoma (HCC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HCC, 8 cirrhotic and 8 control liver specimens were investigated by in situ hybridization and immunohistochemistry respectively, and the level of angiopoietin-2 and Tie2 expression in HCC were compared in terms of tumor biological parameters. It was found that CD34 was not expressed in control liver, expressed scarcely in cirrhotic liver (17.8 +/- 13.5/HP), but intensively expressed in HCC (86.3 +/- 34.8/HP, P0.01). Tie2 receptor was not expressed in controls, expressed at low level in cirrhotic liver (11.3 +/- 8.7/HP), while strongly positive in the microvascular endothelia of HCC (52.4 +/- 16.7/HP, P0.01). The level of Tie2 receptor expression in HCC was closely related with tumor diameter, angiogenesis and portal invasion. Angiopoietin-2 gene was not expressed in control liver, expressed mildly in cirrhotic liver (11.2 +/- 9.7/HP), but extensively in tumor zone (36.4 +/- 17.5/HP), the level of angiopoietin-2 expression was closely related with angiogenesis, portal invasion and histological grading of HCC. It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation, promoting the development and metastasis of human hepatic cancer.
- Subjects :
- Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Neovascularization, Pathologic
Angiogenesis
Liver Neoplasms
CD34
Biology
medicine.disease
Receptor, TIE-2
Angiopoietin receptor
Metastasis
Angiopoietin-2
Management of Technology and Innovation
Hepatocellular carcinoma
embryonic structures
cardiovascular system
medicine
Carcinoma
biology.protein
Humans
Immunohistochemistry
Genes, Tumor Suppressor
Receptor
Subjects
Details
- ISSN :
- 0257716X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Tongji Medical University
- Accession number :
- edsair.doi.dedup.....81346e3fa3af8f7c787600197dde1338