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Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats
- Source :
- Scopus-Elsevier
- Publication Year :
- 2020
-
Abstract
- To assess toxicities of the air in Chinese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products (MBP).Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats (n = 16/group, male: female = 1∶1) were exposed to five different concentrations (95%, 90%, 85%, 80% and 75%, respectively) of MBP for 2 h. For the chronic toxicity study, another three groups of male rats (n = 21/group) were exposed to MBP in three concentrations (10%, 40% and 70%, respectively) and one control group exposed to clean air 20 min/d for 144 d. Routine examinations were performed and analyzed by analysis of variance and dose-response relationship.In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75% groups were 16, 13, 7, 6 and 3, respectively, with LD50 of 86.274% after or during the 2 h exposure. In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the 10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights (P0.05) and lung. Rats in the 70% MBP group also presented with reversible damage in the blood coagulation system (P0.05).Exposure to 10% MBP, which is equivalent to 27.45 mg/m3, was under the critical threshold for male rats' safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation.
- Subjects :
- Lung
business.industry
medicine.medical_treatment
0211 other engineering and technologies
Physiology
02 engineering and technology
General Medicine
Environmental exposure
Moxibustion
010501 environmental sciences
01 natural sciences
Acute toxicity
medicine.anatomical_structure
021105 building & construction
Toxicity
medicine
Breathing
Analysis of variance
business
Chronic toxicity
0105 earth and related environmental sciences
Subjects
Details
- ISSN :
- 2589451X
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
- Accession number :
- edsair.doi.dedup.....8122ebd4adf3890d5dae211eb28b4f37