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Terminal hepatic venule injury in liver biopsies of allogeneic haematopoietic stem cell recipients-a study of 63 cases
- Source :
- Histopathology. 68:996-1003
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Aims Subtle lesions of terminal hepatic venules (THVs) may be overlooked in liver biopsies from haematopoietic stem cell transplant (HSCT) receipients when graft-versus-host disease is the clinical concern. The aim of this study was to evaluate the frequency of THV injury resembling sinusoidal obstruction syndrome (SOS). Methods and results Sixty-three consecutive biopsies from allogeneic HSCT recipients were scored for injured THVs. Forty-nine (78%) biopsies had injured THVs, and 10 (16%) were diagnosed with SOS (mean ± standard deviation of injured THVs/biopsy: 90 ± 9%). Biopsies diagnosed with other diseases also had injured THVs (36 ± 33%). Biopsies from patients with cyclophosphamide plus fractionated total body irradiation conditioning and biopsies taken within 100 days post-HSCT had significantly more occluded THVs (respectively: 40 ± 38%, P = 0.0188; and 35 ± 35%, P = 0.0076) than those with other conditioning regimens or in biopsies taken >100 days post-HSCT. All biopsies taken at any time in the 6-year post-HSCT period had similar amounts of THV phlebosclerosis (23 ± 25%). Conclusions Our results demonstrate a high incidence of THV injuries resembling SOS in post-HSCT liver biopsies. THV injuries were detectable for several years post-HSCT, and were concurrent with other diagnoses. Our results also suggest that SOS may be underdiagnosed.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Histology
Hepatic veno-occlusive disease
Cyclophosphamide
Biopsy
medicine.medical_treatment
Hepatic Veno-Occlusive Disease
Graft vs Host Disease
Hematopoietic stem cell transplantation
Hepatic Veins
Liver transplantation
Gastroenterology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Venules
Internal medicine
medicine
Humans
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Incidence
Incidence (epidemiology)
Hematopoietic Stem Cell Transplantation
Retrospective cohort study
General Medicine
Middle Aged
Total body irradiation
medicine.disease
Liver Transplantation
surgical procedures, operative
Liver
030220 oncology & carcinogenesis
Female
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 03090167
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....8117884c39d4669fc5c2281391838cd9