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Efficacy of Two Doses of RIT 4237 Bovine Rotavirus Vaccine for Prevention of Rotavirus Diarrhoea
- Source :
- Acta Paediatrica. 80:173-180
- Publication Year :
- 1991
- Publisher :
- Wiley, 1991.
-
Abstract
- Vesikari T., Ruuska T., Delem A., Andre F. E., Beards G. M. and Flewett T. H. (Department of Clinical Sciences, University of Tampere, Tampere, Finland, and the Biological Division, Smith Kline RIT Rixensart, Belgium and WHO Collaborating Centre for Reference and Research on Human Rotaviruses, East Birmingham Hospital, Birmingham, U.K.). Efficacy of two doses of RIT 4237 bovine rotavirus vaccine for prevention of rotavirus diarrhoea. Acta Paediatr Scand 80: 173, 1991. Candidate oral bovine rotavirus vaccine RIT 4237 or placebo was given to 252 Finnish infants at birth and at 7 months of age. No vaccine-associated reactions were observed. Primary rotavirus ELISA IgM responses were detected in 36% of the infants after the first vaccination; after the second dose 68% of the vaccinees were seropositive for rotavirus ELISA IgG antibody. The infants remained in clinical follow-up over two rotavirus epidemic seasons (total 28 months). Counted from child years in follow-up the overall vaccine protection rate was 43%. The clinical severity of rotavirus episodes was assessed using numerical score 0–20. Vaccine protection rate for cases with score ≥7 was 57% and for cases with score ≥11 it was 89%. It is concluded that vaccination with bovine rotavirus vaccine at birth and at 7 months of age, with the second dose given shortly before rotavirus epidemic season, protects infants against moderately severe and severe rotavirus diarrhoea in the first 2 years of life.
- Subjects :
- Rotavirus
Pediatrics
medicine.medical_specialty
Reoviridae
Enzyme-Linked Immunosorbent Assay
Vaccines, Attenuated
Placebo
medicine.disease_cause
Rotavirus Infections
Virus
fluids and secretions
Double-Blind Method
medicine
Humans
biology
business.industry
Infant, Newborn
Rotavirus Vaccines
virus diseases
Viral Vaccines
General Medicine
biology.organism_classification
Virology
Antibodies, Anti-Idiotypic
Vaccination
Diarrhea
Immunoglobulin M
El Niño
Immunoglobulin G
Diarrhea, Infantile
Pediatrics, Perinatology and Child Health
Viral disease
medicine.symptom
business
Subjects
Details
- ISSN :
- 16512227 and 08035253
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Acta Paediatrica
- Accession number :
- edsair.doi.dedup.....810eea96b14b60ef04240cef0e2a0932