Back to Search
Start Over
The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial
- Source :
- Am J Perinatol
- Publication Year :
- 2020
- Publisher :
- Georg Thieme Verlag KG, 2020.
-
Abstract
- Objective This study aimed to determine if delayed cord clamping (DCC) affected brain myelin water volume fraction (VFm) and neurodevelopment in term infants. Study Design This was a single-blinded randomized controlled trial of healthy pregnant women with term singleton fetuses randomized at birth to either immediate cord clamping (ICC) (≤ 20 seconds) or DCC (≥ 5 minutes). Follow-up at 12 months of age consisted of blood work for serum iron indices and lead levels, a nonsedated magnetic resonance imaging (MRI), followed within the week by neurodevelopmental testing. Results At birth, 73 women were randomized into one of two groups: ICC (the usual practice) or DCC (the intervention). At 12 months, among 58 active participants, 41 (80%) had usable MRIs. There were no differences between the two groups on maternal or infant demographic variables. At 12 months, infants who had DCC had increased white matter brain growth in regions localized within the right and left internal capsules, the right parietal, occipital, and prefrontal cortex. Gender exerted no difference on any variables. Developmental testing (Mullen Scales of Early Learning, nonverbal, and verbal composite scores) was not significantly different between the two groups. Conclusion At 12 months of age, infants who received DCC had greater myelin content in important brain regions involved in motor function, visual/spatial, and sensory processing. A placental transfusion at birth appeared to increase myelin content in the early developing brain. Key Points
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Sensory processing
medicine.medical_treatment
Article
law.invention
White matter
Myelin
Child Development
Randomized controlled trial
law
Humans
Medicine
Single-Blind Method
Prefrontal cortex
Myelin Sheath
Fetus
medicine.diagnostic_test
business.industry
Infant, Newborn
Brain
Infant
Obstetrics and Gynecology
Magnetic resonance imaging
Magnetic Resonance Imaging
medicine.anatomical_structure
Umbilical Cord Clamping
Pediatrics, Perinatology and Child Health
Serum iron
Female
business
Subjects
Details
- ISSN :
- 10988785 and 07351631
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- American Journal of Perinatology
- Accession number :
- edsair.doi.dedup.....8108feb048d28effabb55ed28ffaf5d6
- Full Text :
- https://doi.org/10.1055/s-0040-1714258