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Morphological change and recovery of corneal endothelial cells after rho-associated protein kinase inhibitor eye-drop (ripasudil 0.4%) instillation
- Source :
- British Journal of Ophthalmology. 105:169-173
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- Background/AimsTo investigate the time-dependent change of corneal endothelial cell (CEC) morphology and density (CECD) in patients with glaucoma post instillation of rho-associated protein kinase inhibitor ripasudil (Rip) 0.4% eye drops.MethodsThis observational study involved 163 eyes of 163 patients with glaucoma in whom CEC morphological change was evaluated by CECD calculated via non-contact specular microscopy (NCSM) before and at 1 or 3 months post-Rip instillation. The change of CECD was plotted along with elapsed time from last instillation of Rip. The patients were divided into the following three groups based on the elapsed time post-Rip instillation: Early Group (ResultsMorphological changes in the CECs appeared within 1 hour and recovered to normal within 6 hours post instillation. In the Early, Middle and Late Group, the median rate of CECD change as calculated by the NCSM automated software was −5.68%, −4.95% and −0.07%, respectively. The CEC images showed the same morphological changes with observational study in all four cases.ConclusionDue to transient morphological changes, the NCSM software produced misleading data for determining CECD within 1 hour post-Rip instillation, yet revealed that CEC morphology gradually recovered to normal within 6 hours.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Glaucoma
Administration, Ophthalmic
Cell Count
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Ophthalmology
Cornea
medicine
Humans
In patient
Enzyme Inhibitors
Rho-associated protein kinase
Intraocular Pressure
Aged
Retrospective Studies
Aged, 80 and over
Sulfonamides
rho-Associated Kinases
business.industry
Endothelium, Corneal
Eye drop
Recovery of Function
Middle Aged
Isoquinolines
medicine.disease
Sensory Systems
medicine.anatomical_structure
chemistry
SPECULAR MICROSCOPY
Female
Ocular Hypertension
Corneal endothelial cell
sense organs
Ripasudil
Ophthalmic Solutions
business
Glaucoma, Open-Angle
Subjects
Details
- ISSN :
- 14682079 and 00071161
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....8106d43055fb56530d452d160689d7d4