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High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese Asian Indian Males with Type 2 Diabetes in North India
- Source :
- Journal of Diabetes Research, Vol 2017 (2017), Journal of Diabetes Research
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- We aimed to correlate plasma glucagon levels with anthropometric measures and abdominal adipose tissue depots. Nonobese males (n=81; BMI 2) with T2DM of less than one-year duration and nonobese males without diabetes (n=30) were evaluated for the following: anthropometry (BMI, waist circumference, W-HR, and truncal skinfolds), whole-body DEXA (for body fat and fat-free mass), and MRI scan (for volumes of subcutaneous abdominal adipose tissue (SCAT) including superficial and deep, intra-abdominal visceral adipose tissue (including intraperitoneal adipose tissue (IPAT), retroperitoneal adipose tissue, liver span and fatty liver, and pancreatic volume)). Plasma glucose and glucagon, serum insulin, hepatic transaminases, and lipid profile were measured. Significantly higher levels of fasting and postprandial glucagon (p<0.001) and fasting and postprandial insulin (p<0.001) were seen in patients with T2DM. The mean values of fasting and postprandial plasma glucagon levels were higher in T2DM patients with NAFLD (n=37) as compared to T2DM patients without NAFLD (n=44). Four independent predictors were derived for fasting glucagon levels in patients with T2DM, namely, W-HR, suprailiac skinfold thickness, IPAT, and deep SCAT (p<0.05; r2=0.84). These observations in Asian Indians may have significance for diabetes therapies which impact glucagon levels.
- Subjects :
- Adult
Male
medicine.medical_specialty
Article Subject
Adolescent
Endocrinology, Diabetes and Metabolism
Abdominal Fat
India
Adipose tissue
030209 endocrinology & metabolism
Type 2 diabetes
Intra-Abdominal Fat
030204 cardiovascular system & hematology
Glucagon
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Young Adult
03 medical and health sciences
0302 clinical medicine
Endocrinology
Waist–hip ratio
Asian People
Internal medicine
Diabetes mellitus
medicine
Humans
Suprailiac Skinfold Thickness
lcsh:RC648-665
Waist-Hip Ratio
business.industry
Fatty liver
nutritional and metabolic diseases
medicine.disease
Skinfold Thickness
Postprandial
Diabetes Mellitus, Type 2
Body Composition
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146753 and 23146745
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....80ff6a5d7ef2fc435de017285f6b9643