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Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression
- Source :
- Archives of pharmacal research. 31(9)
- Publication Year :
- 2008
-
Abstract
- We investigated the synergistic effect of combined treatment with red ginseng acidic polysaccharide (RGAP) from Panax ginseng C.A. Meyer and pidotimod in cyclophosphamide-treated mice. The combination of pidotimod and RGAP restored concanavalin A-induced splenic T cell proliferation and LPS-stimulated B cell proliferation significantly. The production of nitric oxide from peritoneal macrophages was increased by the combinations. NK cell activity was increased by RGAP alone or in combination with pidotimod. A synergistic increase in the level of serum IL-12 and interferongamm was observed when the combination of the two was used. RGAP alone or in combination with pidotimod modulated the level of serum C-reactive protein to a near-normal level. These results indicate that combinations of pidotimod and RGAP are synergistic and suggest that combination therapy using pidotimod and RGAP for improving immune activity may provide an additional benefit over the use of the two drugs by themselves.
- Subjects :
- Male
Combination therapy
Cell Survival
T cell
Panax
Tetrazolium Salts
Biology
Pharmacology
Polysaccharide
Nitric Oxide
Nitric oxide
Ginseng
chemistry.chemical_compound
Mice
Immune system
Adjuvants, Immunologic
Polysaccharides
Drug Discovery
medicine
Animals
Cyclophosphamide
Cell Proliferation
chemistry.chemical_classification
Mice, Inbred BALB C
Organic Chemistry
Body Weight
Drug Synergism
Organ Size
Pyrrolidonecarboxylic Acid
Killer Cells, Natural
Thiazoles
medicine.anatomical_structure
C-Reactive Protein
chemistry
Biochemistry
Concanavalin A
biology.protein
Macrophages, Peritoneal
Molecular Medicine
Thiazolidines
Immunosuppressive Agents
Spleen
Pidotimod
medicine.drug
Subjects
Details
- ISSN :
- 02536269
- Volume :
- 31
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Archives of pharmacal research
- Accession number :
- edsair.doi.dedup.....80faac5ae64b61726645518f0ec20c40