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Hypoxic-Ischemic Damage in the Neonatal Brain: Excitatory Amino Acids
- Source :
- Europe PubMed Central
- Publication Year :
- 1992
- Publisher :
- S. Karger AG, 1992.
-
Abstract
- Perinatal brain damage is a major clinical problem. Recent studies suggest that excitatory amino acids (EAAs) may be important for the development of hypoxic-ischemic brain injury in the newborn. Experimental work demonstrates that the immature brain is hypersensitive to the toxic effects EAA ('excitotoxicity'), hypoxic-ischemia is accompanied by an extracellular overflow of EAAs and hypoxic-ischemic brain damage is reduced by EAA receptor antagonists. Clinical investigations demonstrate the presence of EAA receptors in vulnerable areas of the newborn human brain and the concentrations of EAAs in the cerebrospinal fluid are higher in asphyxiated than in control infants. Clinical studies are warranted to evaluate the importance of excitotoxicity for development of brain lesions after severe asphyxia.
- Subjects :
- medicine.medical_specialty
Excitotoxicity
Brain damage
medicine.disease_cause
Brain Ischemia
Cerebrospinal fluid
Pregnancy
Internal medicine
Neonatal brain
Extracellular
Animals
Humans
Medicine
Pharmacology (medical)
Amino Acids
General Pharmacology, Toxicology and Pharmaceutics
Hypoxia, Brain
Receptor
Asphyxia Neonatorum
biology
business.industry
Excitatory amino-acid transporter
Infant, Newborn
Human brain
Endocrinology
medicine.anatomical_structure
Animals, Newborn
biology.protein
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 25042505 and 03798305
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Developmental Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....80f91821840fc77ddfadaed327536a33