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Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers- results of theESSCAnetwork, 2015-2018
- Source :
- CONTACT DERMATITIS, 84(2), 95-102. Wiley, Whitehouse, H, Uter, W, Geier, J, Ballmer-Weber, B, Bauer, A, Cooper, S, Czarnecka-Operacz, M, Dagmar, S, Dickel, H, Fortina, A B, Gallo, R, Giménez-Arnau, A M, Johnston, G A, Filon, F L, Mahler, V, Pesonen, M, Rustemeyer, T, Schuttelaar, M L A, Valiukevičienė, S, Weisshaar, E, Werfel, T & Wilkinson, M 2021, ' Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers— results of the ESSCA network, 2015-2018 ', Contact Dermatitis, vol. 84, no. 2, pp. 95-102 . https://doi.org/10.1111/cod.13691, Contact Dermatitis, 84(2), 95-102. Wiley-Blackwell
- Publication Year :
- 2021
-
Abstract
- BACKGROUND Studies suggest that patch testing with formaldehyde releasers (FRs) gives significant additional information to formaldehyde 1% aq. and should be considered for addition to the European baseline series (EBS). It is not known if this is also true for formaldehyde 2% aq. OBJECTIVES To determine the frequency of sensitization to formaldehyde 2% aq. and co-reactivity with FRs. To establish whether there is justification for including FRs in the EBS. MATERIALS AND METHODS A 4-year, multi-center retrospective analysis of patients with positive patch test reactions to formaldehyde 2% aq. and five FRs. RESULTS A maximum of 15 067 patients were tested to formaldehyde 2% aq. and at least one FR. The percentage of isolated reactions to FR, without co-reactivity to, formaldehyde 2% aq. for each FR were: 46.8% for quarternium-15 1% pet.; 67.4% imidazolidinyl urea 2% pet.; 64% diazolidinyl urea 2% pet.; 83.3% 1,3-dimethylol-5, 5-dimethyl hydantoin (DMDM) hydantoin 2% pet. and 96.3% 2-bromo-2-nitropropane-1,3-diol 0.5% pet. This demonstrates that co-reactivity varies between FRs and formaldehyde, from being virtually non-existent in 2-bromo-2-nitropropane-1,3-diol 0.5% pet. (Cohen's kappa: 0, 95% confidence interval [CI] -0.02 to 0.02)], to only weak concordance for quaternium-15 [Cohen's kappa: 0.22, 95%CI 0.16 to 0.28)], where Cohen's kappa value of 1 would indicate full concordance. CONCLUSIONS Formaldehyde 2% aq. is an inadequate screen for contact allergy to the formaldehyde releasers, which should be considered for inclusion in any series dependant on the frequency of reactions to and relevance of each individual allergen.
- Subjects :
- Allergic Contact
3-diol
formaldehyde formaldehyde releaser
2-bromo-2-nitropropane-1
Hydantoin
Dermatitis
Nitroparaffin
CONTACT ALLERGY
imidazolidinyl urea
Gastroenterology
DMDM hydantoin
030207 dermatology & venereal diseases
chemistry.chemical_compound
2-bromo-2-nitropropane-1,3-diol
contact allergy
cosmetics
diazolidinyl urea
formaldehyde formaldehyde releasers
quaternium-15
0302 clinical medicine
Urea
Immunology and Allergy
030212 general & internal medicine
610 Medicine & health
PRESERVATIVES
cosmetic
RISK
Patch Test
Allergen
10177 Dermatology Clinic
Patch test
Patch Tests
Imidazolidinyl urea
Dermatitis, Allergic Contact
EUROPEAN SURVEILLANCE SYSTEM
2723 Immunology and Allergy
Human
medicine.medical_specialty
Formaldehyde
Dermatology
Nitroparaffins
2708 Dermatology
Propane
03 medical and health sciences
Internal medicine
Quaternium-15
medicine
Humans
Allergens
Diazolidinyl urea
chemistry
UREA
Subjects
Details
- Language :
- English
- ISSN :
- 01051873
- Database :
- OpenAIRE
- Journal :
- CONTACT DERMATITIS, 84(2), 95-102. Wiley, Whitehouse, H, Uter, W, Geier, J, Ballmer-Weber, B, Bauer, A, Cooper, S, Czarnecka-Operacz, M, Dagmar, S, Dickel, H, Fortina, A B, Gallo, R, Giménez-Arnau, A M, Johnston, G A, Filon, F L, Mahler, V, Pesonen, M, Rustemeyer, T, Schuttelaar, M L A, Valiukevičienė, S, Weisshaar, E, Werfel, T & Wilkinson, M 2021, ' Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers— results of the ESSCA network, 2015-2018 ', Contact Dermatitis, vol. 84, no. 2, pp. 95-102 . https://doi.org/10.1111/cod.13691, Contact Dermatitis, 84(2), 95-102. Wiley-Blackwell
- Accession number :
- edsair.doi.dedup.....80f65ecbde04723692b3bc431a9abebd