Back to Search
Start Over
Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- The standardization of apiceutical products like as propolis extracts has been widely debated worldwide and variations in the propolis chemical composition are still very relevant topics for use-standardized of different propolis-type as medication by much of the world’s population. The present manuscript discuss important issues related to the climate effect and variations in propolis metabolite-profiling changes, antioxidant capacity and variations of the antibacterial activity of the Brazilian red propolis metabolites using comprehensive multivariate correlations. It was observed the increasing of guttiferones concentrations during the intense drought period and drastic decreasing in rainy period. The climate variation induced the high concentration of flavonoids in rainy period with pronounced dropped in some rainy months. The Pearson´s analysis demonstrated correlation between IC50 from DPPH and guttiferones and flavonoids concentrations. The PCA-X and Hotelling T2 test showed outliers during the months with lowest concentrations of formononetin and isoliquiritigenin was observed in antibacterial tests. The PLS-DA, OPLS-DA and VIP analysis demonstrate guttiferone E, guttiferone B, liquiritigenin, naringenin are considered important substances responsible by anti-staphylococcal activity in red propolis composition during the rainy season and drought period, but a synergistic effect with other flavonoids and isoflavonoids are not ruled out.
- Subjects :
- 0301 basic medicine
RM
DPPH
Metabolite
Climate Change
Population
lcsh:Medicine
Biology
01 natural sciences
Antioxidants
Propolis
Article
03 medical and health sciences
chemistry.chemical_compound
Benzophenones
Anti-Infective Agents
Formononetin
Metabolomics
Food science
education
Drug safety
Antiparasitic agents
lcsh:Science
Flavonoids
education.field_of_study
Natural products
Multidisciplinary
010405 organic chemistry
lcsh:R
Antiparasitic agent
0104 chemical sciences
030104 developmental biology
chemistry
lcsh:Q
Seasons
Liquiritigenin
Antibacterial activity
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....80f3ae0b3f5b4b8f4693f812be4f75e6
- Full Text :
- https://doi.org/10.1038/s41598-019-54591-3