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Role of Recombinant Parvalbumin Gad c 1 in the Diagnosis and Prognosis of Fish Allergy
- Source :
- Journal of Investigational Allergology and Clinical Immunology. 30:340-345
- Publication Year :
- 2020
- Publisher :
- Esmon Publicidad, SA, 2020.
-
Abstract
- Background and objectives The prevalence of fish allergy has increased in recent years. The parvalbumin Gad c 1 is a major cod allergen that is used as a follow-up marker in patients with fish allergy. Objectives: To determine the clinical and laboratory characteristics of a population of patients with fish allergy. To analyze the role of the specific IgE (sIgE) of recombinant Gad c 1 (rGad c 1) and skin prick tests (SPTs) in confirming the acquisition of tolerance to fish. Methods We performed a retrospective study of patients with fish allergy from July 1, 2005 to December 31, 2016. The population was characterized according to demographic data, species of fish associated with allergic reactions, and symptoms. The SPT wheal diameter and sIgE for fish and rGad c 1 were evaluated before acquisition of tolerance (T0) and afterwards (T1). Results The study population comprised 81 patients (68% male). Most reactions were triggered by hake (51%), mackerel (30%), and cod (26%). The most frequent manifestations were urticaria/angioedema (72%), gastrointestinal symptoms (35%), and eczema (33%); 42% of patients experienced anaphylaxis. At T0, the average sIgE values were as follows: cod, 32.2 kUA/L; sardine, 18.4 kUA/L; hake, 17.5 kUA/L; salmon, 13.9 kUA/L; tuna, 4.5 kUA/L; and rGad c 1, 22.9 kUA/L. In patients who acquired tolerance to at least 1 fish species (n=60; 74%), the mean value of rGad c 1 at T1 (5.1 kUA/L) was significantly lower than at T0 (16.8 kUA/L) (P=.001). Significant values were also recorded for the average diameter of the SPT wheal and the evaluations at T0 and T1 for hake (9.42 mm/3.79 mm) and salmon (7.8 mm/2.8 mm) (P=.002 and P=.026, respectively). Conclusion The decrease in sIgE to rGad c 1 and the mean wheal diameter of SPT for hake and salmon can be used as markers of prognosis in the acquisition of tolerance by fish-allergic patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Immunology
Population
Mackerel
medicine.disease_cause
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Allergen
Hake
Food allergy
Internal medicine
medicine
Animals
Humans
Immunology and Allergy
030212 general & internal medicine
education
Retrospective Studies
Skin Tests
education.field_of_study
biology
business.industry
Sardine
Fishes
Allergens
Immunoglobulin E
Prognosis
biology.organism_classification
medicine.disease
Recombinant Proteins
Parvalbumins
030228 respiratory system
Population study
Female
business
Food Hypersensitivity
Anaphylaxis
Subjects
Details
- ISSN :
- 10189068
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Investigational Allergology and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....80dfc1d4dce1bdbd6bdcf5bf1ae972ca