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No observed association for mitochondrial SNPs with preterm delivery and related outcomes
- Source :
- Pediatric research
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Background Preterm delivery (PTD) is the leading cause of neonatal morbidity and mortality. Epidemiologic studies indicate recurrence of PTD is maternally inherited creating a strong possibility that mitochondrial variants contribute to its etiology. This study examines the association between mitochondrial genotypes with PTD and related outcomes. Methods This study combined, through meta-analysis, two case-control, genome-wide association studies (GWAS); one from the Danish National Birth Cohort (DNBC) Study and one from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. The outcomes of PTD (≤36 weeks), very PTD (≤32 weeks) and preterm prelabor rupture of membranes (PPROM) were examined. 135 individual SNP associations were tested using the combined genome from mothers and neonates (case vs. control) in each population and then pooled via meta-analysis. Results After meta-analysis there were four SNPs for the outcome of PTD below p≤0.10, and two below p≤0.05. For the additional outcomes of very PTD and PPROM there were three and four SNPs respectively below p≤0.10. Conclusion Given the number of tests no single SNP reached study wide significance (p=0.0006). Our study does not support the hypothesis that mitochondrial genetics contributes to the maternal transmission of PTD and related outcomes.
- Subjects :
- Pediatrics
medicine.medical_specialty
Denmark
Gestational Age
Genome-wide association study
Single-nucleotide polymorphism
Biology
Bioinformatics
DNA, Mitochondrial
Polymorphism, Single Nucleotide
Risk Assessment
Article
03 medical and health sciences
0302 clinical medicine
Risk Factors
Genotype
Odds Ratio
medicine
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
030304 developmental biology
0303 health sciences
Chi-Square Distribution
Norway
Infant, Newborn
Case-control study
Gestational age
Odds ratio
medicine.disease
3. Good health
Phenotype
Premature birth
Case-Control Studies
Pediatrics, Perinatology and Child Health
Etiology
Premature Birth
Infant, Premature
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi.dedup.....80dc08a1185eedf7c8dbb55608e6c2c1