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Effect of brivaracetam on the anger levels of epilepsy patients. A prospective open-labelled controlled study
- Source :
- Seizure. 69:198-203
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Purpose The rate of brivaracetam-related behavioural adverse events is a current focus of discussion. This study aims to assess the effect of brivaracetam on anger levels in patients with epilepsy, adjusted by mood symptoms, history of psychiatric disorders and seizure response. Method Prospective analysis of 37 patients assessed for anger levels (STAXI-2), depression-anxiety (HADS) and quality of life (QOLIE-10) before adjunctive brivaracetam treatment and reassessed 3–6 months later. A control group following the same protocol of assessment was used for 1:1 comparison. A high percentage of mood stabilisers were included in this control group. Results Brivaracetam was indicated for patients including focal onset (79%) and generalised epilepsies (21%). Nearly 60% of responders and no psychiatric adverse events were found. This was similar to controls. The overall results revealed that brivaracetam was assoiciated with better in anger levels, mood scores and quality of life at baseline. Prior use of levetiracetam or the presence of a psychiatric background did not influence the results. However, improvements in anger levels were seen in the brivaracetam responders. Conclusion This study shows that brivaracetam is not associated with an increased level of anger in patients with either focal or generalised epilepsies in the absence of psychiatric comorbidity. However, an improvement in anger levels is possibly influenced by a good seizure response.
- Subjects :
- Adult
Male
medicine.medical_specialty
media_common.quotation_subject
Comorbidity
Anger
Brivaracetam
03 medical and health sciences
Epilepsy
0302 clinical medicine
Quality of life
Internal medicine
mental disorders
medicine
Humans
In patient
Prospective Studies
Adverse effect
media_common
Psychiatric Status Rating Scales
business.industry
Mental Disorders
General Medicine
Middle Aged
medicine.disease
Pyrrolidinones
Treatment Outcome
Mood
Neurology
Quality of Life
Anticonvulsants
Female
Neurology (clinical)
Levetiracetam
business
030217 neurology & neurosurgery
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 10591311
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Seizure
- Accession number :
- edsair.doi.dedup.....80d4f06c03cc03b976e58d1f69e7f4e5