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Predicting Hepatic Steatosis in Living Liver Donors Via Controlled Attenuation Parameter
- Source :
- Transplantation Proceedings. 50:3533-3538
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Hepatic steatosis (HS) can cause substantial problems for both donors and recipients in living donor liver transplantation. The controlled attenuation parameter (CAP) is a noninvasive method of measuring HS using a process based on transient elastography.To evaluate the accuracy of CAP in quantifying HS during living donor liver transplantation.A total of 54 liver donors who received CAP and intraoperative liver biopsy (LB) were enrolled in this study. The performance of CAP compared with LB for diagnosing HS was assessed using areas under receiver operating characteristic curves. HS was defined by the presence of steatosis in5% of hepatocytes.No HS was found in 47 donors, while the remaining 7 donors showed HS ranging from 10% to 30%. Using CAP, the area under receiver operating characteristic curve was 0.96 (95% CI, 0.91-1; P .001) for HS; the optimal cutoff value for HS was 257 dB/m (sensitivity: 100%, specificity: 89.4%, positive predictive value: 58.3%, negative predictive value: 100%). Among the 42 candidates with CAP 257 dB/m, none had HS, while of the 12 candidates with CAP ≥257 dB/m, 7 had HS. In a multivariate linear regression analyses, body mass index (β = 0.71, P .001) was found to be independently associated with CAP in those without HS.CAP might be a promising tool to exclude HS in East Asian living liver donors. Body mass index was found to be independently associated with CAP values in those without HS.
- Subjects :
- Adult
Male
medicine.medical_specialty
Biopsy
medicine.medical_treatment
Transplants
Liver transplantation
Severity of Illness Index
Gastroenterology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Asian People
Predictive Value of Tests
Internal medicine
Living Donors
medicine
Humans
Transplantation
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Middle Aged
medicine.disease
Liver Transplantation
Fatty Liver
ROC Curve
Area Under Curve
030220 oncology & carcinogenesis
Liver biopsy
Predictive value of tests
Multivariate Analysis
Linear Models
Elasticity Imaging Techniques
Female
030211 gastroenterology & hepatology
Surgery
Steatosis
Transient elastography
business
Body mass index
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....80ccd300ce0a7f4060aebd474196a2bf