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Role for apolipoprotein E in neurodegeneration and mercury intoxication
- Source :
- Frontiers in bioscience (Elite edition). 10(2)
- Publication Year :
- 2017
-
Abstract
- Mercury intoxication is a serious public health problem and a worldwide concern. The Minamata Convention on Mercury has been signed by 128 countries and endorsed by the World Health Organization with the recommendation of promoting the management of epidemiological information. The Central Nervous System is the main target organ for mercury. Symptoms of intoxication include altered motor coordination, visual and tactile dysfunction and paralysis, caused by neurodegeneration with a key role for oxidative damage. Recently, some studies have demonstrated a correlation between mercury intoxication and isoforms of apolipoprotein E (ApoE). In this review, epidemiological data and hypotheses about the possible molecular mechanisms underlying the association between ApoE and mercury intoxication are assessed. Based on the evidence and the neuropathological changes that the presence of ApoE4 and mercury neurotoxicity have in common, we propose a convergent action of both factors. ApoE4 seems to potentiate the damage caused by mercury. Increased knowledge of this interaction using epidemiological and pre-clinical studies is essential to improve prevention strategies to adequately manage intoxicated patients.
- Subjects :
- 0301 basic medicine
Apolipoprotein E
medicine.medical_specialty
chemistry.chemical_element
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
World health
Minamata Convention on Mercury
03 medical and health sciences
0302 clinical medicine
Apolipoproteins E
Epidemiology
Medicine
Humans
General Immunology and Microbiology
business.industry
Neurodegeneration
Neurotoxicity
Neurodegenerative Diseases
medicine.disease
Mercury (element)
030104 developmental biology
chemistry
Mercury Poisoning
business
030217 neurology & neurosurgery
Target organ
Subjects
Details
- ISSN :
- 19450508
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Frontiers in bioscience (Elite edition)
- Accession number :
- edsair.doi.dedup.....80cc79e0d4a13f2ab2e1bbc8592db59c