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Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: The Swedish national March cohort
- Publication Year :
- 2018
- Publisher :
- Oxford University Press, 2018.
-
Abstract
- Background: Results from randomized trials of antioxidant supplementation have cast doubt on observational data linking diets high in antioxidants to a reduced risk of cardiovascular diseases. We hypothesized that supplementation of one or a few antioxidants might not simulate the complex actions of all antioxidants in the human diet. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), reflecting the antioxidant potential of the whole diet, and the risk of myocardial infarction (MI). Methods: In the Swedish National March Cohort, 34 543 men and women free from cardiovascular diseases and cancer were followed through record linkages from 1997 until 2010. NEAC was assessed with a validated food-frequency questionnaire at baseline. The distribution of NEAC was categorized into sex-specific quartiles. We fitted multivariable Cox proportional hazards regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Results: During a mean follow-up time of 12.7 years, we identified 1142 incident cases of MI. Successively higher quartiles (Qs) of dietary NEAC were accompanied by a monotonic trend of decreasing MI incidence, both for overall MI (HR Q4 vs Q1: 0.77; 95% CI: 0.61–0.96; p for trend ¼ 0.008) and non-fatal MI (HR Q4 vs Q1: 0.72; 95% CI: 0.56–0.92; p for trend ¼ 0.004). No such association was found for fatal MI. Conclusions: A diet rich in antioxidants might protect from MI.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Epidemiology
Myocardial Infarction
Non-enzymatic antioxidant capacity
Antioxidants
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Prospective cohort study
Multivariate Analysi
Proportional Hazards Models
Aged
Sweden
030109 nutrition & dietetics
business.industry
Proportional hazards model
Incidence (epidemiology)
Incidence
Risk Factor
Hazard ratio
General Medicine
Middle Aged
medicine.disease
Atherosclerosis
Confidence interval
Diet
Prospective Studie
Quartile
Atherosclerosi
Multivariate Analysis
Cohort
Proportional Hazards Model
Female
Antioxidant
business
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....80bd7e95d406a7b1fe3d4610b7a74934