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Cerebral Microdialysis Effects of Propofol versus Midazolam in Severe Traumatic Brain Injury
- Source :
- Journal of Neurotrauma, Journal of Neurotrauma, 2012, 29 (6), pp.1105-10. ⟨10.1089/neu.2011.1817⟩, Journal of Neurotrauma, Mary Ann Liebert, 2012, 29 (6), pp.1105-10. ⟨10.1089/neu.2011.1817⟩
- Publication Year :
- 2012
- Publisher :
- Mary Ann Liebert Inc, 2012.
-
Abstract
- International audience; Propofol, an anesthetic agent acting as an analogue of vitamin E, has been advocated to be an ideal neuroprotective agent both in animal models and in clinical practice, due to its positive effects on oxidative stress. Nevertheless, no studies have compared this agent to another sedative agent used for sedation after traumatic brain injury (TBI). The objective was to compare the effects of propofol to midazolam on cerebral biomarkers at the acute phase of severe TBI patients. Thirty patients aged 35±18 years were prospectively randomized to receive propofol or midazolam and 29 were analyzed (n=15 for propofol, and n=14 for midazolam). A cerebral microdialysis catheter was used to measure the lactate:pyruvate (L:P) ratio, glutamate, glycerol, and glucose for 72 h. No difference between groups was observed for the L:P ratio (time effect p=0.201, treatment effect p=0.401, time×treatment interaction p=0.101). Similarly, no difference was observed for glutamate (time effect p=0.930, treatment effect p=0.651, time×treatment interaction p=0.353), glycerol (time effect p=0.223, treatment effect p=0.922, time×treatment interaction p=0.308), or glucose (time effect p=0.116, treatment effect p=0.088, time×treatment interaction p=0.235). These results do not support a difference between propofol and midazolam for sedation for the cerebral metabolic profile in severe TBI.
- Subjects :
- Glycerol
Male
Microdialysis
medicine.medical_treatment
0302 clinical medicine
MESH: Hypnotics and Sedatives
Pyruvic Acid
Hypnotics and Sedatives
Single-Blind Method
MESH: Microdialysis
MESH: Brain Chemistry
030212 general & internal medicine
Propofol
Cerebral Cortex
Glutamate receptor
MESH: Neuroprotective Agents
MESH: Glutamic Acid
3. Good health
MESH: Glucose
Neuroprotective Agents
MESH: Propofol
Anesthesia
Female
medicine.symptom
medicine.drug
Adult
Traumatic brain injury
Midazolam
Sedation
Glutamic Acid
Neuroprotection
03 medical and health sciences
MESH: Glycerol
medicine
Humans
Lactic Acid
MESH: Pyruvic Acid
Brain Chemistry
MESH: Humans
business.industry
Vitamin E
MESH: Biological Markers
MESH: Adult
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
MESH: Single-Blind Method
medicine.disease
MESH: Male
MESH: Cerebral Cortex
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Glucose
Brain Injuries
MESH: Midazolam
MESH: Brain Injuries
MESH: Lactic Acid
Neurology (clinical)
business
MESH: Female
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15579042 and 08977151
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Neurotrauma
- Accession number :
- edsair.doi.dedup.....80ba282406d05e1e5c37f337173358a9