Back to Search
Start Over
Improvement of hyperglycaemia and metabolic syndromes in type 2 diabetic KKAy mice by oral treatment with [meso-tetrakis(4-sulfonatophenyl) porphyrinato]oxovanadium(IV)(4-) complex
- Source :
- The Journal of pharmacy and pharmacology. 59(3)
- Publication Year :
- 2007
-
Abstract
- Recently, we reported that [meso-tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium(IV)(4-), VO(tpps), shows in-vitro insulin-mimetic and in-vivo anti-diabetic activity in streptozotocin (STZ)-induced type 1 diabetic mice. This result prompted us to examine its ability in type 2 diabetic model KKAy mice with insulin resistance. We studied the in-vivo anti-diabetic activity of VO(tpps), compared with that of vanadium(IV) oxide sulfate, VS, as control. Both compounds were orally administered at doses of 5–10 mg (0.1-0.2 mmol) V/kg body weight to the KKAy mice for 28 days. VO(tpps) normalized the hyperglycaemia within 15 days, while VS lowered the blood glucose concentration only by a small degree. In addition, metabolic syndromes characterized by insulin and leptin resistance were significantly improved in VO(tpps)-treated KKAy mice compared with those treated with VS. The improvement in diabetes was validated by oral glucose tolerance test and decrease in HbA1c concentration. Based on these observations, VO(tpps) is proposed to be an orally active oxovanadium(IV)-porphyrin complex for treating not only type 2 diabetes but also metabolic syndromes in animals.
- Subjects :
- Leptin
Male
medicine.medical_specialty
Oral treatment
Metalloporphyrins
medicine.medical_treatment
Pharmaceutical Science
Oxovanadium IV
Type 2 diabetes
Body weight
Mice
Insulin resistance
Internal medicine
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Pharmacology
Glycated Hemoglobin
Chemistry
Insulin
Glucose Tolerance Test
medicine.disease
Streptozotocin
Endocrinology
Diabetes Mellitus, Type 2
Hyperglycemia
Insulin Resistance
medicine.drug
Subjects
Details
- ISSN :
- 00223573
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of pharmacy and pharmacology
- Accession number :
- edsair.doi.dedup.....80a640ff57afe288bed0c7df53d8fe50