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Serum NX-DCP as a New Noninvasive Model to Predict Significant Liver Fibrosis in Chronic Hepatitis C
- Source :
- Hepatitis Monthly
- Publication Year :
- 2015
- Publisher :
- Briefland, 2015.
-
Abstract
- Background: Finding a noninvasive method to predict liver fibrosis using inexpensive and easy-to-use markers is important. Objectives: We aimed to clarify whether NX-des-γ-carboxyprothrombin (NX-DCP) could become a new noninvasive model to predict liver fibrosis in hepatitis C virus (HCV) related liver disease. Patients and Methods: We performed a prospective cohort study on a consecutive group of 101 patients who underwent liver biopsy for HCV-related liver disease at Kobe University Hospital. Laboratory measurements were performed on the same day as the biopsy. Factors associated with significant fibrosis (F3-4) were assessed by multivariate analyses. A comparison of predictive ability between multivariate factors and abovementioned noninvasive models was also performed. Results: Increase in serum NX-DCP was significantly related to increase in fibrosis stage (P = 0.006). Moreover, NX-DCP was a multivariate factor associated with the presence of significant fibrosis F 3-4 (median 21 of F0-2 group vs. median 22 of F3-4 group with P = 0.002). The AUC of NX-DCP showed no significant differences compared with those of the AST-to-platelet ratio index (APRI), modified-APRI, the Göteborg University Cirrhosis Index (GUCI), the Lok index, the Hui score, cirrhosis discriminating score (CDS) and the Pohl score (P > 0.05). Conclusions: NX-DCP correlated positively with fibrosis stage and could discriminate well between HCV-related patients with or without significant fibrosis. Moreover, NX-DCP had a similar predictive ability to the abovementioned models, and thereby could be a new noninvasive prediction tool for fibrosis.
- Subjects :
- Pathology
medicine.medical_specialty
Cirrhosis
Hepatology
medicine.diagnostic_test
business.industry
Biopsy
Liver fibrosis
des-Gamma-Carboxy Prothrombin
Fibrosis stage
Hepatitis C
medicine.disease
Gastroenterology
Kowsar
Infectious Diseases
Chronic hepatitis
Fibrosis
Internal medicine
medicine
Liver Fibrosis
Chronic
business
Research Article
Subjects
Details
- ISSN :
- 17353408 and 1735143X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Hepatitis Monthly
- Accession number :
- edsair.doi.dedup.....809d345992159366ed94c9dc9386d36a