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Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- We investigated the impact of pre-percutaneous coronary intervention (pre-PCI) thrombolysis in myocardial infarction (TIMI) flow grade (pre-TIMI) on 3-month (3-mo) and 12-mo of dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (AMI). This was a post hoc analysis of the TICO trial. A total of 2083 patients with AMI (pre-TIMI 0/1: n = 1143; pre-TIMI 2/3: n = 940) were evaluated. The primary outcome was the occurrence of net adverse clinical events (NACE), defined as a composite of TIMI major bleeding and major adverse cardiac and cerebrovascular events (MACCE) within 12-mo following PCI. The secondary outcomes were the occurrence of the individual components of TIMI bleedings and MACCE. In the pre-TIMI 0/1 group, the primary and second outcomes were not significantly different between the 3-mo and 12-mo DAPT groups. However, in the pre-TIMI 2/3 group, the occurrences of TIMI minor (adjusted hazard ratio [aHR]: 0.294; p = 0.016) and major or minor bleeding (aHR: 0.483; p = 0.014) on intention-to-treat analysis were significantly higher in the 12-mo than in the 3-mo DAPT group. The occurrence of MACCE was similar between the two groups. A higher bleeding tendency in 12-mo DAPT compared with 3-mo DAPT was more obvious in the pre-TIMI 2/3 group than in the pre-TIMI 0/1 group.Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02494895.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Science
Cardiology
Myocardial Infarction
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
Medical research
Percutaneous Coronary Intervention
Internal medicine
Coronary Circulation
Post-hoc analysis
medicine
Humans
030212 general & internal medicine
Myocardial infarction
cardiovascular diseases
Coronary flow
Aged
Multidisciplinary
Duration of Therapy
business.industry
Hazard ratio
Thrombolysis
Middle Aged
medicine.disease
Clinical trial
Patient Outcome Assessment
surgical procedures, operative
Conventional PCI
Heart Function Tests
Preoperative Period
Medicine
Female
business
TIMI
Biomarkers
Platelet Aggregation Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....8092c2513e961c93fa5431722c950316