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Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system
- Source :
- Nephrology Dialysis Transplantation. 18:497-506
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Background. An increase in urinary albumin excretion (UAE) represents an early predictor of glomerular damage in diabetes mellitus (DM) and a risk factor for cardiovascular complications in hypertension. Vasopressin is elevated in DM and in some forms of hypertension. Previous studies in rats suggested that this hormone could play a role in the albuminuria observed in chronic renal failure or diabetic nephropathy, but no information is available concerning the mechanism of these effects and the possible influence of vasopressin on UAE in the healthy kidney. The present study was thus designed to evaluate whether vasopressin influences UAE in normal rats and humans, whether this effect is V 2 -receptor-dependent, and whether it is mediated by the renin-angiotensin system. Methods. UAE was measured in normal Wistar rats and healthy humans, or in subjects with various forms of diabetes insipidus (DI), before and after acute or chronic infusion of the vasopressin V 2 receptor agonist dDAVP®. Chronic dDAVP administration was also performed in normal Wistar rats previously submitted to either chronic angiotensin-converting enzyme inhibition (ACEI) or chronic blockade of ATI receptors (ARB). Results. In rats, acute or chronic dDAVP infusion increased UAE significantly and reversibly (4-fold and 6-fold, respectively). In healthy subjects, acute infusion of dDAVP tripled UAE (P
- Subjects :
- Adult
Male
Receptors, Vasopressin
medicine.medical_specialty
Vasopressin
Vasopressins
Blood Pressure
Renal Agents
urologic and male genital diseases
Renin-Angiotensin System
Diabetic nephropathy
chemistry.chemical_compound
Reference Values
Internal medicine
Diabetes mellitus
medicine
Albuminuria
Animals
Humans
Deamino Arginine Vasopressin
Transplantation
Creatinine
business.industry
medicine.disease
Rats
Endocrinology
chemistry
Nephrology
Aquaporin 2
Diabetes insipidus
Female
Microalbuminuria
medicine.symptom
business
Diabetes Insipidus
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14602385
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....80865293c9cd9c450b5495d52fcdfcbc
- Full Text :
- https://doi.org/10.1093/ndt/18.3.497