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Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system

Authors :
Daniel G. Bichet
Pascale Bardoux
Marie-Françoise Arthus
Michel Marre
Lise Bankir
Michèle Lonergan
Hélène Martin
Yves Gallois
Nicole Ruel
Nadine Bouby
Source :
Nephrology Dialysis Transplantation. 18:497-506
Publication Year :
2003
Publisher :
Oxford University Press (OUP), 2003.

Abstract

Background. An increase in urinary albumin excretion (UAE) represents an early predictor of glomerular damage in diabetes mellitus (DM) and a risk factor for cardiovascular complications in hypertension. Vasopressin is elevated in DM and in some forms of hypertension. Previous studies in rats suggested that this hormone could play a role in the albuminuria observed in chronic renal failure or diabetic nephropathy, but no information is available concerning the mechanism of these effects and the possible influence of vasopressin on UAE in the healthy kidney. The present study was thus designed to evaluate whether vasopressin influences UAE in normal rats and humans, whether this effect is V 2 -receptor-dependent, and whether it is mediated by the renin-angiotensin system. Methods. UAE was measured in normal Wistar rats and healthy humans, or in subjects with various forms of diabetes insipidus (DI), before and after acute or chronic infusion of the vasopressin V 2 receptor agonist dDAVP®. Chronic dDAVP administration was also performed in normal Wistar rats previously submitted to either chronic angiotensin-converting enzyme inhibition (ACEI) or chronic blockade of ATI receptors (ARB). Results. In rats, acute or chronic dDAVP infusion increased UAE significantly and reversibly (4-fold and 6-fold, respectively). In healthy subjects, acute infusion of dDAVP tripled UAE (P

Details

ISSN :
14602385
Volume :
18
Database :
OpenAIRE
Journal :
Nephrology Dialysis Transplantation
Accession number :
edsair.doi.dedup.....80865293c9cd9c450b5495d52fcdfcbc
Full Text :
https://doi.org/10.1093/ndt/18.3.497