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Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications

Authors :
Abdul Rauf
A. A. Farooq
Lubna Shahzadi
Aqif Anwar Chaudhry
Ihtesham Ur Rehman
Abdul Samad Khan
Muhammad Yar
Nasir Mahmood
Source :
Materials Science and Engineering: C. 64:148-156
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

Periodontal disease is associated with the destruction of periodontal tissues, along with other disorders/problems including inflammation of tissues and severe pain. This paper reports the synthesis of meloxicam (MX) immobilized biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) based electrospun (e-spun) fibers and films. Electrospinning was employed to produce drug loaded fibrous mats, whereas films were generated by solvent casting method. In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release. During initial first few hours fast release was noted from membranes and films; however after around 5h sustained release was achieved. The hydrogels showed good swelling property, which is highly desired for soft tissue engineered implants. To investigate the biocompatibility of our synthesized materials, VERO cells (epithelial cells) were selected and cell culture results showed that these all materials were non-cytotoxic and also these cells were very well proliferated on these synthesized scaffolds. These properties along with the anti-inflammatory potential of our fabricated materials suggest their effective utilization in periodontital treatments.

Details

ISSN :
09284931
Volume :
64
Database :
OpenAIRE
Journal :
Materials Science and Engineering: C
Accession number :
edsair.doi.dedup.....80789da4f336fdfdfd2d803f02cb85c5
Full Text :
https://doi.org/10.1016/j.msec.2016.03.072