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Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications
- Source :
- Materials Science and Engineering: C. 64:148-156
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Periodontal disease is associated with the destruction of periodontal tissues, along with other disorders/problems including inflammation of tissues and severe pain. This paper reports the synthesis of meloxicam (MX) immobilized biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) based electrospun (e-spun) fibers and films. Electrospinning was employed to produce drug loaded fibrous mats, whereas films were generated by solvent casting method. In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release. During initial first few hours fast release was noted from membranes and films; however after around 5h sustained release was achieved. The hydrogels showed good swelling property, which is highly desired for soft tissue engineered implants. To investigate the biocompatibility of our synthesized materials, VERO cells (epithelial cells) were selected and cell culture results showed that these all materials were non-cytotoxic and also these cells were very well proliferated on these synthesized scaffolds. These properties along with the anti-inflammatory potential of our fabricated materials suggest their effective utilization in periodontital treatments.
- Subjects :
- Ceramics
Vinyl alcohol
Materials science
Biocompatibility
Thiazines
Bioengineering
Nanotechnology
Biodegradable Plastics
02 engineering and technology
Meloxicam
Polyvinyl alcohol
Biomaterials
Chitosan
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Chlorocebus aethiops
medicine
Animals
Vero Cells
Periodontal Diseases
Drug Implants
Membranes, Artificial
030206 dentistry
021001 nanoscience & nanotechnology
Electrospinning
Thiazoles
Durapatite
Membrane
chemistry
Chemical engineering
Mechanics of Materials
Polyvinyl Alcohol
Self-healing hydrogels
Swelling
medicine.symptom
0210 nano-technology
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....80789da4f336fdfdfd2d803f02cb85c5
- Full Text :
- https://doi.org/10.1016/j.msec.2016.03.072