MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life

MET exon 14 alterations are a diverse group of mutations, many of which disrupt splice acceptor or donor sites leading to exon 14 skipping, impaired receptor degradation, and oncogenic transformation. These alterations are clinically targetable with MET-directed therapy. Clin Cancer Res; 22(12); 2832–4. ©2016 AACR. See related article by Tong et al., p. 3048