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Lipid peroxidation products formation with various intravenous iron preparations in chronic kidney disease
- Source :
- Renal failure. 31(2)
- Publication Year :
- 2009
-
Abstract
- The role of intravenous iron in contributing to oxidative stress and endothelial dysfunction in chronic kidney disease (CKD) is debatable. The present study assessed differences in fasting plasma malondialdehyde (pMDA) levels 30 minutes before and after intravenous infusion of low molecular weight iron dextran (ID) (n = 19), iron-sucrose (IS) (n = 20), and sodium ferrigluconate complex (SFGC) (n = 20) in stage 3 and 4 CKD patients. Post-infusion pMDA levels were significantly raised with respect to baseline (p0.001). pMDA was significantly higher in the SFGC group vs. IS (3.02 +/- 0.84 micromol/L vs. 2.82 +/- 0.44 micromol/L, p = 0.034) or SFGC vs. ID (3.02 +/- 0.84 micromol/L vs. 2.92 +/- 0.20 micromol/L, p = 0.048). There was no difference between IS vs. ID (2.82 +/- 0.44 micromol/L vs. 2.92 +/- 0.20 micromol/L, p = 0.21). To conclude, all forms of parenteral iron, especially SFGC, significantly raise pMDA levels in the immediate post-transfusion period.
- Subjects :
- Nephrology
Adult
Male
medicine.medical_specialty
Resuscitation
Pathology
Critical Care and Intensive Care Medicine
medicine.disease_cause
Ferric Compounds
Lipid peroxidation
chemistry.chemical_compound
Internal medicine
Malondialdehyde
medicine
Humans
Endothelial dysfunction
Infusions, Intravenous
Anemia, Iron-Deficiency
business.industry
General Medicine
Middle Aged
medicine.disease
Endocrinology
Dextran
chemistry
Kidney Failure, Chronic
Female
Lipid Peroxidation
business
Oxidative stress
Kidney disease
Subjects
Details
- ISSN :
- 15256049
- Volume :
- 31
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Renal failure
- Accession number :
- edsair.doi.dedup.....8074f5f9a22357bdb6a68fa2a5f0b229